Centro Nacional de Investigaciones Cientifica, La Habana, Cuba
Degree: Doctor of Philosophy
Cholera is an ancient waterborne diarrheal disease caused by Vibrio cholerae of serogroup O1 and O139 that continues to affects impoverished populations worldwide. Our research in the biology of V. cholerae covers a broad range of cellular processes relevant to cholera prevention, treatment, pathogenesis and transmission.
Wang, H., J.C. Ayala, J.A. Benitez, and A.J. Silva. 2014. The LuxR-type regulator VpsT negatively controls the transcription
of rpoS encoding the general stress response regulator in Vibrio cholerae biofilms. J. Bacteriol. 196: 1020-1030.
Wang, H., A.J. Silva, L. Rasmussen, E.L. White, and J.A. Benitez. 2013. A highly specific cell-based high throughput screening (HTS) assay for ligands of Gram-negative bacteria cyclic AMP receptor protein. ASSAY and Drug Develop. Technol. 11: 382-387.
Wang, H., L. Zhang, A.J. Silva, and J.A. Benitez. 2013. A quinazoline 2, 4 diamino analog suppresses Vibrio cholerae flagellar motility by interacting with the motor protein PomB and induces envelope stress. Antimicrob. Agents Chemother. 57: 3950-3959.
Wang, H., J.C Ayala, A.J. Silva, and J.A. Benitez. 2012. The histone-like nucleoid structuring protein (H-NS) is a repressor of Vibrio cholerae exopolysaccharide biosynthesis (vps) genes. Appl. Environ. Microbiol. 78: 2482-2488.
Wang, H., J.C Ayala, J.A. Benitez, and A.J. Silva. 2012. Interaction of the histone-like nucleoid structuring protein (H-NS) and the general stress response regulator RpoS at Vibrio cholerae promoters that regulate motility and hemagglutinin (HA)/protease expression. J. Bacteriol. 194: 1205-1215.
Wang, H., J-H. Wu, J.C. Ayala, J.A. Benitez, and A.J. Silva. 2011. Interplay between cyclic diguanylate, HapR and the general stress response regulator (RpoS) in the regulation of Vibrio cholerae hemagglutinin (HA)/protease. J. Bacteriol. 193: 6529-6538.
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Honors and Awards
Alexander von Humboldt Foundation (Bonn, Germany) Research Fellow
Outstanding service as an online mentor of the American Society for Microbiology Minority Mentoring Program