Dr. Erika T. Brown

Erika T. Brown, Ph.D. 

ASSOCIATE DEAN

Faculty Affairs & Development

ASSOCIATE PROFESSOR

Department of Pathology & Anatomy
Location: Hugh Gloster Building, Room B-138
Phone: 404-752-1742
E-mail: etbrown@msm.edu

Education

POSTGRADUATE
University of Colorado Health Sciences Center
Postdoctoral Research: Senior Research Associate - Oncology, Cancer Biology and Radiation Biology

Vanderbilt University Medical Center
Postdoctoral:
Postdoctoral Fellow - Oncology, Cancer Biology and Radiation Biology

GRADUATE:

University of Alabama at Birmingham
Degree: Doctor of Philosophy in Medical Genetics

Spelman College
Degree: Bachelor of Science in Biology/Biochemistry

Research Interests

Breast cancer genes (BRCA1 and BRCA2)

Triple negative breast cancer

DNA damage and repair pathways

Community-based Breast Cancer health disparity studies

Publications

Toole, William P. and Erika T. Brown, “Alterations in chemotherapeutic sensitivity of carcinoma cells that overexpress the DNA repair protein RAD51”, (in preparation).

Hwang, HeeYoung, Patel, Vedang R. and Erika T. Brown, “Inhibition of RAD51 activity during S phase increases the chemotherapeutic sensitivity of carcinoma cells”, (in preparation).

Holt, Jeffrey T., Toole, William P., Patel, Vedang R., Hwang, HeeYoung, and Erika T. Brown, “Restoration of CAPAN-1 cells with functional BRCA2 provides insight into the DNA repair activity of individuals who are heterozygous for BRCA2 mutations”, Cancer Genet Cytogenet. 2008 Oct 15; 186(2):85-94.

Brown, Erika T. and Jeffrey T. Holt.  “Rad51 overexpression rescues radiation resistance in BRCA2-defective cancer cells”.  Mol Carcinog. 2009 Feb; 48(2):105-9.

Brown, Erika T. and Gerald M. Fuller, “Detection of a Protein Complex Associated with the G-455-A Polymorphism”, Blood, Vol. 92, No. 9, Nov. 1, 1998: pp. 3286-3293.

Mousavi-Shafaei, Parisa, Turner, B, Cao, Juxiang, Schulte, Jennifer, Lane A, Paulsen C, Jezierska, Agnieska, Brown, Erika T., Carroll,  K, Ball, Lauren, Helke, Kristine, Garret-Mayer, Elizabeth, Manevich, Y and Carola A. Neumann, “The Peroxidase Peroxiredoxin1 (Prdx1) promotes Rad-51 in DNA double strand repair”, (under review).

Hwang, HeeYoung, Patel, Vedang R. and Erika T. Brown, “An in vitro study of inhibition of RAD51 as a target for chemotherapeutic treatment of breast carcinomas”, (under revision for re-submission).

Venkata, Jagadish Kummetha, Hinsch, Claire Leist, Spyropoulous, Demetri, Brown, Erika, Watkins, Simon C., and Vincent Dammai, “RAT pathway synchronizes FGFR1 signaling by intracellular sequestration and controlled PM delivery of the receptor”, (under review, JCB)

Brown, Erika T., Robinson-Benion, Cheryl and Jeffrey T. Holt, “Radiation Enhances Caspase 3 Cleavage of Rad51 in BRCA2-Defective Cells”, Radiat Res. 2008 May; 169(5):595-601.

Elhammer, Ake P., Poorman, Roger A., Brown, Erika, Maggiora, Linda L., Hoogerheide, John G., and Ferenc J. Kezdy, “The Specificity of UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase as Inferred from a Database of in Vivo Substrates and from the in Vitro Glycosylation of Proteins and Peptides”, The Journal of Biological Chemistry, Vol. 268, No. 14, May 15, 1993: pp. 10029-10038.

Nagathihalli, N.S. and Brown, E.T. (2013). Pancreatic cancer progression, metastasis and DNA repair. In L. Mathews & E. Hurt (Eds.). DNA Repair and Cancer Stem Cells (pp. 141-155). New York, New York: Springer Publishing Company. (In press)

Brown, E.T. (2011). BRCA2 mutations and consequences for DNA repair. In I. Kruman (Ed.), DNA Repair (pp. 327-340).  Rijeka, Croatia: InTech Publishers.   

Honors and Awards

2012 Minority Scientist Spotlight, American Society for Biochemistry and Molecular Biology (ASBMB)

Sigma Xi Scientific Honor Society, Faculty Member Induction (2010)

Top 15 Instructors, MUSCCollege of Graduate Studies

Young Investigator Travel Award: University of Texas M.D. Anderson Cancer Center 55th Annual Symposium on Fundamental Cancer Research (2002)

American Association for Cancer Research-MICR Scholar in Cancer Research Award (2001, 2003)

Fellowship: UNCF-Pfizer Postdoctoral Fellow (2000-2001)

Fellowship: NIH-NCI National Research Service Award--Postdoctoral Fellow (1999-2000)

Fellowship: GAANN Pre-doctoral Fellow (1997-1999)

Fellowship:  CMFSDP Pre-doctoral Fellow (1993-1997)

First Place—American Society for Cell Biology Education/MAC Pre-doctoral Poster Award (1997)

UMARC Scholar, Spelman College/Morehouse School of Medicine, Atlanta, GA, May 1991-May 1993