Xuebiao Yao, Ph.D. 

Professor

Physiology

Location: Medical Education Building 349
Phone: 404-752-1894
E-mail: xyao@msm.edu

Education

POSTGRADUATE: 
University of California-San Diego 
Residency: 
Cancer Cell Biology

GRADUATE: 
University of California-Berkeley
Degree: 
Doctor of Philosophy in Molecular Cell Biology

UNDERGRADUATE: 
Jiangxi Medical College
Degree:
Bachelor of Science in Medicine/Pharmacology

Research Interests

Cellular mechanisms involved in establishment and maintenance of cell polarity using gastric epithelial cells as a model system.

How Helicobacter pylori cytotoxins such as VacA perturb genomic stability of gastric parietal cells using a novel 3D culture system.

Mitotic chromosome segregation and genomic stability: 

Protein-protein interactions at the kinetochore is orchestrated during cell division and what happens when specific protein-protein interaction is perturbed in real-time live cells using optical reporters.

Publications

Yu H, Zhou J, Takahashi H, Yao W, Suzuki Y, Yuan X, Yoshimura SH, Zhang Y, Liu Y, Emmett N, Bond V, Wang D, Ding X, Takeyasu K, Yao X. Spatial control of proton pump H,K-ATPase docking at the apical membrane by phosphorylation-coupled ezrin-syntaxin 3 interaction. J Biol Chem. 2014 Oct 9. pii: jbc.M114.581280. PMID: 25301939

Lu H, Zhao Q, Jiang H, Zhu T, Xia P, Seffens W, Aikhionbare F, Wang D, Dou Z, Yao X. Characterization of ring-like f-actin structure as a mechanical partner for spindle positioning in mitosis. PLoS One. 2014 Oct 9;9(10):e102547. doi: 10.1371/journal.pone.0102547. eCollection 2014. PMID: 25299690

Chu L, Huo Y, Liu X, Yao P, Thomas K, Jiang H, Zhu T, Zhang G, Chaudhry M, Adams G, Thompson W, Dou Z, Jin C, He P, Yao X. The Spatiotemporal Dynamics of Chromatin Protein HP1α Is Essential for Accurate Chromosome Segregation during Cell Division. J Biol Chem. 2014 Sep 19;289(38):26249-62. doi: 10.1074/jbc.M114.581504. Epub 2014 Aug 7. PMID: 25104354

Liu X, Song Z, Huo Y, Zhang J, Zhu T, Wang J, Zhao X, Aikhionbare F, Zhang J, Duan H, Wu J, Dou Z, Shi Y, Yao X.  Chromatin Protein HP1α Interacts with the Mitotic Regulator Borealin Protein and Specifies the Centromere Localization of the Chromosomal Passenger Complex. J Biol Chem. 2014 Jul 25;289(30):20638-20649. Epub 2014 Jun 10. PMID: 24917673

Xia P, Zhou J, Song X, Wu B, Liu X, Li D, Zhang S, Wang Z, Yu H, Ward T, Zhang J, Li Y, Wang X, Chen Y, Guo Z, Yao X. Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interaction. J Mol Cell Biol. 2014 Jun;6(3):240-54. doi: 10.1093/jmcb/mju016. Epub 2014 May 20. PMID: 24847103

Mehrabi S, Partridge EE, Seffens W, Yao X, Aikhionbare FO. Oxidatively modified proteins in the serous subtype of ovarian carcinoma. Biomed Res Int. 2014;2014:585083. doi: 10.1155/2014/585083. Epub 2014 Mar 27. PMID: 24795885


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