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  • Selected Publications

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  • Original Scientific Articles and Reviews

    1. Hellstrand K, Asea A, Hermodsson S. Role of histamine in natural killer cell-mediated resistance against tumor cells. J Immunol 1990;145:4365-4370.
    2. Hellstrand K, Kylefjord H, Asea A, Hermodsson S. Regulation of the natural killer cell response to interferon-alpha by biogenic amines. J Interferon Res 1992;12:199-206.
    3. Hellstrand K, Czerkinsky C, Ricksten A, Jansson B, Asea A, Kylefjord H, Hermodsson S. Role of serotonin in the regulation of interferon-gamma production by human natural killer cells. J Interferon Res 1993;13:33-38.
    4. Hellstrand K, Asea A, Dahlgren C, Hermodsson S. Histaminergic regulation of NK cells. Role of monocyte-derived reactive oxygen metabolites. J Immunol 1994;153:4940-4947.
    5. Hellstrand K, Asea A, Hermodsson S. Histaminergic regulation of antibody-dependent cellular cytotoxicity of granulocytes, monocytes, and natural killer cells. J Leukoc Biol 1994;55:392-397.
    6. Asea A. Role of histamine in the regulation of natural killer cells. Doctoral dissertation, University of Göteborg, Göteborg, Sweden: 1995;1:1-88.
    7. Hellstrand K, Asea A, Hermodsson S. Role of histamine in natural killer cell-dependent protection against herpes simplex virus type 2 infection in mice. Clin Diagn Lab Immunol 1995;2:277-280.
    8. Asea A, Hansson M, Czerkinsky C, Houze T, Hermodsson S, Strannegard O, Hellstrand K. Histaminergic regulation of interferon-gamma (IFN-gamma) production by human natural killer (NK) cells. Clin Exp Immunol 1996;105:376-382.
    9. Asea A, Hermodsson S, Hellstrand K. Histaminergic regulation of natural killer cell-mediated clearance of tumour cells in mice. Scand J Immunol 1996;43:9-15.
    10. Hansson M, Asea A, Ersson U, Hermodsson S, Hellstrand K. Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites. J Immunol 1996;156:42-47.
    11. Hansson M, Asea A, Hermodsson S, Hellstrand K. Histaminergic regulation of NK-cells: protection against monocyte-induced apoptosis. Scand J Immunol 1996;44:193-196.
    12. Houze TA, Larsson L, Larsson PA, Hansson G, Asea A, Gustavsson B. Rapid detection of thymidylate synthase gene expression levels by semi-quantitative competitive reverse transcriptase polymerase chain reaction followed by quantitative digital image analysis. Tumour Biol 1996;17:306-319.
    13. Jonsdottir IH, Asea A, Hoffmann P, Dahlgren UI, Andersson B, Hellstrand K, Thoren P. Voluntary chronic exercise augments in vivo natural immunity in rats. J Appl Physiol 1996;80:1799-1803.
    14. Jonsdottir IH, Asea A, Hoffmann P, Hellstrand K, Thoren P. Natural immunity and chronic exercise in rats. The involvement of the spleen and the splenic nerves. Life Sci 1996;58:2137-2146.
    15. Jonsdottir IH, Johansson C, Asea A, Hellstrand K, Hoffmann P. Acute mental stress but not enforced muscle activity transiently increases natural cytotoxicity in spontaneously hypertensive rats. Acta Physiol Scand 1996;157:443-449.
    16. Jonsdottir IH, Johansson C, Asea A, Hellstrand K, Thoren P, Hoffmann P. Chronic intracerebroventricular administration of beta-endorphin augments natural killer cell cytotoxicity in rats. Regul Pept 1996;62:113-118.
    17. Cvetkovska E, Asea A, Hellstrand K, Edstrom S. Tumor suppressive action of indomethacin is NK-cell-independent. Anticancer Res 1997;17:3403-3407.
    18. Jonsdottir IH, Johansson C, Asea A, Johansson P, Hellstrand K, Thoren P, Hoffmann P. Duration and mechanisms of the increased natural cytotoxicity seen after chronic voluntary exercise in rats. Acta Physiol Scand 1997;160:333-339.
    19. Stein-Streilein J, Asea A, Montalvo J, Maniaci V, Wanner A. Role of NK1.1+ cells in immune regulation. Periodicum Biologrum 1997;23:34-39.
    20. Asea A, Stein-Streilein J. Signalling through NK1.1 triggers NK cells to die but induces NK T cells to produce interleukin-4. Immunology 1998;93:296-305.
    21. Stevenson MA, Zhao MJ, Asea A, Coleman CN, Calderwood SK. Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes. J Immunol 1999;163:5608-5616.
    22. Xie Y, Cahill CM, Asea A, Auron PE, Calderwood SK. Heat shock proteins and regulation of cytokine expression. Infect Dis Obstet Gynecol 1999;7:26-30.
    23. Asea A, Kabingu E, Stevenson MA, Calderwood SK. HSP70 peptide-bearing and peptide-negative preparations act as chaperokines. Cell Stress & Chaperones 2000;5:425-431.
    24. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, Calderwood SK. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nature Medicine 2000;6:435-442.
    25. He H, Chen C, Xie Y, Asea A, Calderwood SK. HSP70 and heat shock factor 1 cooperate to repress Ras-induced transcriptional activation of the c-fos gene. Cell Stress & Chaperones 2000;5:406-411.
    26. Hecker KH, Asea A, Kobayashi K, Green S, Tang D, Calderwood SK. Mutation detection in the human HSP7OB' gene by denaturing high-performance liquid chromatography. Cell Stress & Chaperones 2000;5:415-424.
    27. Soncin F, Asea A, Zhang X, Stevenson MA, Calderwood SK. Role of calcium activated kinases and phosphatases in heat shock factor-1 activation. Int J Mol Med 2000;6:705-710.
    28. Wang X, Asea A, Xie Y, Kabingu E, Stevenson MA, Calderwood SK. RSK2 represses HSF1 activation during heat shock. Cell Stress & Chaperones 2000;5:432-437.
    29. Asea A, Ara G, Teicher BA, Stevenson MA, Calderwood SK. Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo. Int J Hyperthermia 2001;17:347-356.
    30. Asea A, Mallick R, Lechpammer S, Ara G, Teicher BA, Fiorentino S, Stevenson MA, Calderwood SK. Cyclooxygenase inhibitors are potent sensitizers of prostate tumours to hyperthermia and radiation. Int J Hyperthermia 2001;17:401-414.
    31. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, Calderwood SK. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 2002;277:15028-15034.
    32. Calderwood SK, Asea A. Targeting HSP70-induced thermotolerance for design of thermal sensitizers. Int J Hyperthermia 2002;18:597-608.
    33. Lechpammer S, Asea A, Mallick R, Zhong R, Sherman MY, Calderwood SK. Development of an XTT tetrazolium salt-based assay for detection of specific hyperthermia sensitizers in a high-flux screening programme. Int J Hyperthermia 2002;18:203-215.
    34. Noessner E, Gastpar R, Milani V, Brandl A, Hutzler PJ, Kuppner MC, Roos M, Kremmer E, Asea A, Calderwood SK, Issels RD. Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells. J Immunol 2002;169:5424-5432.
    35. Zhao M, Tang D, Lechpammer S, Hoffman A, Asea A, Stevenson MA, Calderwood SK. Double-stranded RNA-dependent protein kinase (pkr) is essential for thermotolerance, accumulation of HSP70, and stabilization of ARE-containing HSP70 mRNA during stress. J. Biol. Chem. 2002;277:44539-44547.
    36. Asea A. Chaperokine-induced signal transduction pathways. Exercise Immunology Review 2003;9:25-33.
    37. Barreto A, Gonzalez JM, Kabingu E, Asea A, Fiorentino S. Stress-induced release of HSC70 from human tumors. Cell Immunol. 2003;222:97-104.
    38. Soncin F, Zhang X, Chu B, Wang X, Asea A, Ann Stevenson M, Sacks DB, Calderwood SK. Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2. Biochem. Biophys. Res. Commun. 2003;303:700-706.
    39. Bausero MA, Page DT, Osinaga E, Asea A. Surface expression of Hsp25 and Hsp72 differentially regulates tumor growth and metastasis. Tumour Biol. 2004;25:243-251.
    40. Terry DF, McCormick M, Andersen S, Pennington J, Schoenhofen E, Palaima E, Bausero M, Ogawa K, Perls TT, Asea A. 2004. Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Ann. N Y Acad. Sci. 2004;1019:502-505.
    41. Adewoye AH, Klings ES, Farber HW, Palaima E, Bausero MA, McMahon L, Odhiambo A, Surinder S, Yoder M, Steinberg MH, Asea A. Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70. Am. J. Hematol. 2005;78:240-242.
    42. Asea A. Heat shock proteins and tumors. Modern Aspects in Immunology 2005;17:10-10.
    43. Asea A. Stress proteins and initiation of immune response: chaperokine activity of hsp72. Exerc. Immunol. Rev. 2005;11:34-45.
    44. Bausero MA, Gastpar R, Multhoff G, Asea A. Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72. J. Immunol. 2005;175:2900-2912.
    45. Gastpar R, Gehrmann M, Bausero MA, Asea A, Gross C, Schroeder JA, Multhoff G. Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res. 2005;65:5238-5247.
    46. Asea A. Initiation of the immune response by extracellular Hsp72: chaperokine activity of Hsp72. Curr. Immunol. Rev. 2006;2:209-215.
    47. Bausero MA, Bharti A, Page DT, Perez KD, Eng JW, Ordonez SL, Asea EE, Jantschitsch C, Kindas-Muegge I, Ciocca D, Asea A. Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell. Tumour Biol. 2006;27:17-26.
    48. Svensson PA, Asea A, Englund MC, Bausero MA, Jernas M, Wiklund O, Ohlsson BG, Carlsson LM, Carlsson B. Major role of HSP70 as a paracrine inducer of cytokine production in human oxidized LDL treated macrophages. Atherosclerosis 2006;185:32-38.
    49. Terry DF, Wyszynski DF, Nolan VG, Atzmon G, Schoenhofen EA, Pennington JY, Andersen SL, Wilcox MA, Farrer LA, Barzilai N, Baldwin CT, Asea A. Serum heat shock protein 70 level as a biomarker of exceptional longevity. Mech. Ageing Dev. 2006;127:862-868.
    50. Asea A. Mechanisms of HSP72 release. J. Biosci. 2007;32:579-584.
    51. Asea AA, Milani V, Calderwood SK. Heat shock proteins in physiology and pathology: the Berlin meeting. Cell Stress & Chaperones 2007;12:205-208.
    52. Asea A. Heat shock proteins and toll-like receptors. Handb. Exp. Pharmacol. 2008;183:111-127.
    53. Asea A. Hsp70: a chaperokine. Novartis Found Symp 2008;291:173-179; discussion 179-183 and 221-174.
    54. Asea A, Jean-Pierre C, Kaur P, Rao P, Linhares IM, Skupski D, Witkin SS. Heat shock protein-containing exosomes in mid-trimester amniotic fluids. J Reprod Immunol 2008;79:12-17.
    55. Gross C, Holler E, Stangl S, Dickinson A, Pockley AG, Asea AA, Mallappa N, Multhoff G. An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation. Leuk Res 2008;32:527-534.
    56. Stangl S, Gross C, Pockley AG, Asea AA, Multhoff G. Influence of Hsp70 and HLA-E on the killing of leukemic blasts by cytokine/Hsp70 peptide-activated human natural killer (NK) cells. Cell Stress Chaperones 2008;13:221-230.
    57. Urueña CP, Cifuentes C, Castañeda DM, Arango AD, Kaur P, Asea AA, Fiorentino S. Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells. BMC Complement Altern. Med. 2008;8:60-66.
    58. Ortega E, Hinchado MD, Martin-Cordero L, Asea A. The effect of stress-inducible extracellular Hsp72 on human neutrophil chemotaxis: a role during acute intense exercise. Stress 2009;12:240-249.
    59. Panossian A, Wikman G, Kaur P, Asea A. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. Phytomedicine 2009;16:617-622.
    60. Zheng H, Nagaraja GM, Kaur P, Asea EE, Asea A. Chaperokine function of recombinant Hsp70 produced in insect cells using a baculovirus expression system is intact. J. Biol. Chem. 2010;285:349-356.
    61. Kaur P, Chakraborti A, Asea A. Enteroaggregative Escherichia coli: an emerging food borne pathogen. Interdiscipl. Perspec. Infect. Dis. 2010:254159.
    62. Kaur P, Reis MD, Couchman GR, Forjuoh SN, Greene Jr JF, Asea A. SERPINE1 links obesity and diabetes: a pilot study. J. Proteomics Bioinform. 2010;3:191-199.
    63. Hurwitz MD, Kaur P, Nagaraja GM, Bausero MA, Asea A. Radiation therapy induces circulating serum Hsp72 in patients with prostate cancer. Radiother & Oncol. 2010;95:350-358.
    64. Vareed SK, Bhat VB, Thompson C, Vasu VT, Fermin D, Hyungwon C, Creighton CJ, Gayatri S, Lan L, Putluri N, Thangjam GS, Kaur P, Shabahang M, Giri JG, Nesvizhskii AI, Asea A, Cashikar AG, Rao A, McLoughlin J, Sreekumar A. Metabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma. PLoS ONE 2011;6:e17177.
    65. Afroze SH, Uddin MN, Cao X, Asea A and Gizachew D. 2011. Internalization of exogenous ADP-ribosylation factor 6 (Arf6) proteins into cells. Mol. Cell Biochem. 2011;354:291-299.
    66. Kaur P, Nagaraja GM, Asea, A. Combined lentiviral and RNAi technologies for the delivery and permanently silencing of the hsp25 gene. Meth. Mol. Biol. 2011;787:121-136.
    67. Kaur P, Asea A. Quantitation Methods for heat shock proteins in clinical samples using mass spectrometry. Meth. Mol. Biol. 2011;787:165-188.
    68. Kaur P, Hurwitz MD, Krishnan S, Asea A. Combined hyperthermia and radiotherapy for the eradication of cancer. Cancers 2011;3:3799-3823.
    69. Upreti M, Jamshidi-Parsian A, Koonce NA, Webber JS, Sharma SK, Asea AA, Mader MJ, Griffin RJ. Tumor-endothelial cell three-dimensional spheroids: new aspects to enhance radiation and drug therapeutics. Translational Oncology 2011:4:365–376.
    70. Nagaraja GM, Kaur P, Neumann W, Asea EE, Bausero MA, Multhoff G, Asea A. Silencing hsp25/hsp27 gene expression augments proteasome activity and increases CD8+ T cell-mediated tumor killing and memory responses. Cancer Prev Res (Phila). 2012;5:122-137. (Figure featured on journal cover).
    71. Siepermann M, Koscielniak E, Dantonello T, Klee D, Boos J, Krefeld B, Borkhardt A, Hoehn T, Asea A, Wessalowski R. Oral low-dose chemotherapy: successful treatment of an alveolar rhabdomyosarcoma during pregnancy. Pediatric Blood and Cancer 2012;58:104-106.
    72. Panossian A, Kaur P, Wikman G, Asea A. Rhodiola rosea L. extract SHR-5 and salidroside stimulate neuropeptide Y expression in neuroglia cells. Frontiers Neuroscience. 2012;6:1-12.
    73. Campisi J, Sharkey C, Johnson JD, Asea A, Maslanik T, Bernstein-Hanley I, Fleshner M. Stress-induced facilitation of host response to bacterial challenge is dependent on extracellular Hsp72 and independent of α -T cells. Stress 2012 Jan 4. [Epub ahead of print]. doi: 10.3109/10253890.2011.653596.
    74. Kaur P, Nagaraja GM, Zheng H, Gizachew D, Galukande M, Krishnan S, Asea A. A mouse model for triple-negative breast cancer tumor-initiating cells (TNBC-TICs) exhibits similar aggressive phenotype to the human disease. BMC Cancer 2012;12:120-128.
    75. Nagaraja GM, Kaur P, Asea A. Role of human and mouse HspB1 in metastasis. Current Molecular Medicine 2012 Jul 17. [Epub ahead of print].
    76. Kaur P, Asea A. Radiation-induced effects and the immune system in cancer. Frontiers in Mol Cell Oncol (in press).
    77. Urueña C, Mancipe J, Hernandez J, Castañeda D, Pombo M, Gomez A, Asea A, Fiorentino S. Gallotannin-rich Caesalpinia spinosa fraction decreases the primary tumor and factors associated with poor prognosis in a murine breast cancer model. BMC Cancer (in press).

    Books and Book Chapters

    1. Asea A, Calderwood SK. Regulation of signal transduction by intracellular and extracellular Hsp70. In The Extracellular Biology of Molecular Chaperones, eds. B Henderson, AG Pockley. London: Cambridge University Press. 2005;1:133-143.
    2. Nagaraja GM, Asea A. Heat shock proteins, function and immunobiology. In Heat Shock Proteins in Biology and Medicine, eds. G Multhoff, J Radons. Kerala, India: Research Signpost Press. 2006;1:1-16.
    3. Asea A, DeMaio A. Heat Shock Proteins: Potent Mediators of Inflammation and Immunity. Dordrecht, The Netherlands: Springer. 2007;357 pp.
    4. Asea A. Release of heat shock proteins: passive vs active release mechanisms. In Heat Shock Proteins: Potent Mediators of Inflammation and Immunity, eds. A Asea, A De Maio. Dordrecht, The Netherlands: Springer. 2007;1:3-20.
    5. Bausero MA, Asea A. Role of Hsp25/27 in metastatic spread of cancer cells. In Heat Shock Proteins in Cancer, eds. SK Calderwood, D Ciocca. Dordrecht, The Netherlands: Springer. 2007;2:131-140.
    6. Terry DF, Asea A. Serum heat shock protein 70 level as a biomarker of exceptional longevity. In Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection, eds. A Asea, IR Brown. Dordrecht, The Netherlands: Springer. 2008;3:365-370.
    7. Singh NK, Rao P, Asea A. Silencing of metastasis-associated gene 1 (mta1) stimulates Hsp70 cellular release and neurite extension in neuroblastoma cells. In Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection, eds. A Asea, IR Brown. Dordrecht, The Netherlands: Springer. 2008;3:273-282.
    8. Asea A, Brown IR. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection. Dordrecht, The Netherlands: Springer. 2008;373 pp.
    9. Kaur P, Asea A. Toll-like receptors and infectious diseases: role of heat shock proteins. In Heat Shock Proteins in Infectious Disease, eds. SK Calderwood, AG Pockley, G Santoro. Dordrecht, The Netherlands: Springer. 2009;4:153-167.
    10. Asea A, Pedersen BK. Heat Shock Proteins and Whole Body Physiology. Dordrecht, The Netherlands: Springer. 2010;429 pp.
    11. Kaur P, Reis MD, Couchman GR, Forjuoh SN, Greene Jr JF, Asea A. Role of heat shock proteins in obesity and type 2 diabetes. In Heat Shock Proteins and Whole Body Physiology, eds. A Asea, BK Pedersen. Dordrecht, The Netherlands: Springer. 2010;5:19-29.
    12. Nagaraja GM, Asea A. Heat shock proteins and cancer. In Heat Shock Proteins and Whole Body Physiology, eds. A Asea, BK Pedersen. Dordrecht, The Netherlands: Springer. 2010;5:121-134.
    13. Zheng H, Asea A. Heat shock proteins and immunotherapy. In Heat Shock Proteins and Whole Body Physiology, eds. A Asea, BK Pedersen. Dordrecht, The Netherlands: Springer. 2010;5:135-149.
    14. Kaur P, Asea A. Heat shock proteins and diarrhea causing bacteria. In Heat Shock Proteins and Whole Body Physiology, eds. A Asea, BK Pedersen. Dordrecht, The Netherlands: Springer. 2010;5:163-175.
    15. Panossian A, Wikman G, Kaur P, Asea A. Molecular chaperones as mediators of stress protective effect of plant adaptogens. In Heat Shock Proteins and Whole Body Physiology, eds. A Asea, BK Pedersen. Dordrecht, The Netherlands: Springer. 2010;5:351-364.
    16. Kaur P, Asea A. The chaperokine activity of HspA1A. In Extracellular Heat Shock Proteins, eds. AG Pockley, B Henderson. Dordrecht, The Netherlands: Springer. 2012 (in press).
    17. Kaur P, Pradeep ANR, Asea A. Nucleolin: a novel intracellular transporter of HspA1A. In Extracellular Heat Shock Proteins, eds. AG Pockley, B Henderson. Dordrecht, The Netherlands: Springer. 2012 (in press).