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BS., University of Havana School of Biochemistry and Pharmacy
Ph.D., University of Havana College of Biological Sciences
Vibrio cholerae, the causative agent of Asiatic cholera, colonizes the human small bowel and causes a potentially life-threatening watery diarrhea. V. cholerae of serogroups O1 and O139 continues to cause seasonal cholera outbreaks that affect highly populated regions in Asia, Africa and Latin America. The objective of our research is to understand the regulatory mechanism involved in V. cholerae colonization of the small intestine, its release to the aquatic environment and persistence outside the human host. To this end we are using genetic and genomic approaches to study the role of global regulators in the expression of virulence, motility and biofilm formation. These studies will facilitate the development of improved vaccines and therapeutic agents to prevent and treat cholera. We have shown that V. cholerae live attenuated vaccines can be used as antigen delivery vectors to induce protective immunity against other pathogens. We are working to improve current cholera vaccines by expressing foreign antigens that could afford cross protection to other diseases that share similar geographic and socioeconomic pattern.
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