| Contact Information | | Phone: (404) 752-1504 Fax: (404) 752-1978 Email: sanford@msm.edu | | Education B.A., Miles College Ph.D., Brown University Research Interests My laboratory is actively involved in three distinct areas of research: 1) investigating the cellular and molecular adaptation of endothelial cells to modeled microgravity; 2) studying the mechanisms of vasculogenesis during early embryonic lung development; and 3) the role of nitric oxide, COX-2 and galectin-3 in breast cancer metastasis. The first area of research will provide a better understanding of the underlying cellular mechanism(s) responsible for changes in the way vascular cells, and other cells functions under altered gravity environments (e.g., during space flights). The second research area is to understand how extracellular mediators, e.g., laminin and fibronectin, are involved in a vasculogenesis process, and may contribute to the development congenital lung disorders. The last area of research is to assess the metastatic potential (adhesion, migration and invasion) of breast cancer cells in response to a COX-2 inhibition, addition of a NO-donor, or by exogenous galectin-3. Click <a href="My laboratory is actively involved in three distinct areas of research: 1) investigating the cellular and molecular adaptation of endothelial cells to modeled microgravity; 2) studying the mechanisms of vasculogenesis during early embryonic lung development; and 3) the role of nitric oxide, COX-2 and galectin-3 in breast cancer metastasis. The first area of research will provide a better understanding of the underlying cellular mechanism(s) responsible for changes in the way vascular cells, and other cells functions under altered gravity environments (e.g., during space flights). The second research area is to understand how extracellular mediators, e.g., laminin and fibronectin, are involved in a vasculogenesis process, and may contribute to the development congenital lung disorders. The last area of research is to assess the metastatic potential (adhesion, migration and invasion) of breast cancer cells in response to a COX-2 inhibition, addition of a NO-donor, or by exogenous galectin-3. Click here to view selected publications. |