• Selected Publications

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    1. Singh R, Stockard CR, Grizzle WE, Lillard JW, Jr. and Singh S. Expression and histopathological correlation of CCR9 and CCL25 in Ovarian Cancer. International Journal of oncology. 2011 (in press).

    2. Singh R, Lillard JW, Jr. and Singh S. Chemokines: Key players in cancer progression and metastasis. Front Biosc. 2011 (in press).

    3. Singh R, Singh S, Briles DE, Taub DD, Hollingshead SK and Lillard JW, Jr. CCL5-independent Helper T Lymphocyte Responses to Immuno-dominant Pneuomococcal Surface Protein A Epitopes. Vaccine, 2011 (in press).

    4. El-Haibi CP, Singh R, Sharma P, Singh S, and Lillard JW, Jr. CXCL13 selectively regulates the DOCK2/JNK signalling cascade to promote prostate cancer cell invasion and proliferation. Cell Proliferation. 2011 (in press).

    5. Johnson-Holiday C, Singh R, Johnson EL, Grizzle WE, Lillard, JW Jr and Singh S. CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion. World J Surg Oncol. 2011, 9(1): 46.

    6. Johnson-Holiday C, Singh R, Johnson EL, Grizzle WE, Singh S, and Lillard JW, Jr. CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cell in a CCR9-dependent fashion. Int J Oncol. 2011;38(5):1279-85.

    7. Johnson EL, Singh R, Johnson-Holiday CM, Grizzle WE, Partridge EE, Singh S, and Lillard JW, Jr. CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion. World J Surg Oncol. 2010; 8(1): 62.

    8. Johnson EL, Singh R, Johnson-Holiday CM, Grizzle WE, Partridge EE, Lillard JW, Jr, and Singh S. CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion. J Ovarian Res. 2010; 3 (1): 15.

    9. El-Haibi, CP, Sharma, P, Johnson PR, Singh R, Suttles J, Singh S, and Lillard, J.W. Jr.*. PI3Kp110-, Src, and FAK-dependent and DOCK2-independent migration and invasion by CXCL13-stimulated prostate cancer cells. Mol. Cancer. 2010; 9(1): 85.

    10. Singh R, Singh S, Sharma PK, Singh UP, Briles DE, Hollingshead SK, Lillard JW Jr.* 2010. Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A. PLoS One. 2010; 5(2): e9432.

    11. Sharma PK, Singh R, Novakovic KR, Eaton JW, Grizzle WE, Singh S. CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide. Int J Cancer. 2010; 127(9): 2020-30.

    12. Singh S, Singh R, Singh UP, Rai SN, Novakovic KR, Chung LW, Didier PJ, Grizzle WE, Lillard JW Jr. Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines. Int J Cancer. 2009; 125(10): 2288-95.

    13. Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, Cooper CR, Novakovic KR, Grizzle WE, Lillard JW Jr. Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett. 2009; 283(1): 29-35.

    14. Singh S, Bond VC, Powell M, Singh UP, Bumpers HL, Grizzle WE, Lillard JW Jr. CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth. Mol Cancer Ther. 2009;8(1): 178-84.

    15. Sakthivel SK, Singh UP, Singh S, Taub DD, Novakovic KR, Lillard JW Jr. CXCL10 blockade protects mice from cyclophosphamide-induced cystitis. J Immune Based Ther Vaccines. 2008; 6: 6.

    16. Sakthivel SK, Singh UP, Singh S, Taub DD, Igietseme JU, Lillard JW Jr. CCL5 regulation of mucosal chlamydial immunity and infection. BMC Microbiol. 2008; 8:136.

    17. Singh UP, Singh R, Singh S, Karls RK, Quinn FD, Taub DD, Lillard JW Jr. CXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis. BMC Immunol. 2008; 9:25.

    18. Singh UP, Singh S, Singh R, Cong Y, Taub DD, Lillard JW Jr. CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-) mice, which can be abrogated by anti-CXCL10 antibody inhibition. J Interferon Cytokine Res. 2008; 28(1): 31-43.

    19. Singh R, Singh S, Lillard JW Jr. Past, present, and future technologies for oral delivery of therapeutic proteins. J Pharm Sci. 2008; 97(7): 2497-523

    20. Singh UP, Singh S, Singh R, Karls RK, Quinn FD, Potter ME, Lillard JW Jr. Influence of Mycobacterium avium subsp. paratuberculosis on colitis development and specific immune responses during disease. Infect Immun. 2007; 75 (8): 3722-8.

    21. Palaniappan R, Singh S, Singh UP, Singh R, Ades EW, Briles DE, Hollingshead SK, Royal W 3rd, Sampson JS, Stiles JK, Taub DD, Lillard JW Jr. CCL5 modulates pneumococcal immunity and carriage. J Immunol. 2006; 176(4): 2346-56.

    22. Larkins TL, Nowell M, Singh S, Sanford GL Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. BMC Cancer. 2006; 6:181.

    23. He Q, Moore TT, Eko FO, Lyn D, Ananaba GA, Martin A, Singh S, James L, Stiles J, Black CM, Igietseme JU. Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response. J Immunol. 2005; 174(8): 4860-9.

    24. Sarfo BY, Armah HB, Irune I, Adjei AA, Olver CS, Singh S, Lillard JW Jr, Stiles JK.Plasmodium yoelii 17XL infection up-regulates RANTES, CCR1, CCR3 and CCR5 expression, and induces ultrastructural changes in the cerebellum. Malar J. 2005; 16(4): 63.

    25. Palaniappan R, Singh S, Singh UP, Sakthivel SK, Ades EW, Briles DE, Hollingshead SK, Paton JC, Sampson JS, Lillard JW Jr. Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage. Infect Immun. 2005; 73(2): 1006-13.

    26. Singh S, Singh UP, Stiles JK, Grizzle WE, Lillard JW Jr. Expression and functional role of CCR9 in prostate cancer cell migration and invasion. Clin Cancer Res. 2004; 10(24): 8743-50.

    27. Singh UP, Singh S, Ravichandran P, Taub DD, Lillard JW Jr. Viral macrophage-inflammatory protein-II: a viral chemokine that differentially affects adaptive mucosal immunity compared with its mammalian counterparts. J Immunol. 2004; 173(9): 5509-16.

    28. Singh S, Singh UP, Grizzle WE, Lillard JW Jr. CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab Invest. 2004; 84(12): 1666-76

    29. Singh UP, Singh S, Boyaka PN, McGhee JR, Lillard JW Jr. Granulocyte chemotactic protein-2 mediates adaptive immunity in part through IL-8Rbeta interactions. J Leukoc Biol. 2004; 76(6): 1240-7.

    30. Sarfo BY, Singh S, Lillard JW Jr, Quarshie A, Gyasi RK, Armah H, Adjei AA, Jolly P, Stiles JK. The cerebral-malaria-associated expression of RANTES, CCR3 and CCR5 in post-mortem tissue samples. Ann Trop Med Parasitol. 2004; 98(3): 297-303.

    31. Shukla VK, Prakash A, Chauhan VS, Singh S. Puneet Biliary nitrate and risk of carcinoma of the gallbladder. Eur J Cancer Prev. 2004;13(4):355-6.

    32. Pandey M, Sharma LB, Singh S, Shukla VK. Erythrocyte membrane fatty acid profile and saturation index in gallbladder carcinogenesis: a case-control study. World J Surg Oncol. 2003; 1(1):5.

    33. Singh UP, Singh S, Iqbal N, Weaver CT, McGhee JR, Lillard JW Jr. IFN-gamma-inducible chemokines enhance adaptive immunity and colitis. J Interferon Cytokine Res. 2003; 23(10): 591-600.

    34. Singh UP, Singh S, Taub DD, Lillard JW Jr. Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10-/- mice. J Immunol. 2003; 171(3): 1401-6.

    35. Lillard JW Jr, Singh UP, Boyaka PN, Singh S, Taub DD, McGhee JR. MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity. Blood. 2003; 101(3): 807-14.

    36. Lillard JW Jr, Boyaka PN, Singh S, McGhee JR. Salmonella-mediated mucosal cell mediated immunity. Cell Mol Biol. 2001; 47(7): 1115-20.

    37. Dixit VK, Singh S, Shukla VK. Aetiopathogenesis of carcinoma gallbladder. Trop Gastroenterol. 2001; 22(2): 103-6.

    38. Shukla VK, Rastogi AN, Adukia TK, Raizada RB, Reddy DC, Singh S. Organochlorine pesticides in carcinoma of the gallbladder: a case-control study. Eur J Cancer Prev. 2001; 10(2): 153-6.

    39. Pandey M, Shukla VK, Singh S, Roy SK, Rao BR. Biliary lipid peroxidation products in gallbladder cancer: increased peroxidation or biliary stasis? Eur J Cancer Prev. 2000; 9(6): 417-22.

    40. Agarwal M, Agarwal AK, Singh S, Shukla VK. An ultrasonographic evaluation of gallbladder emptying in patients with cholelithiasis. J Clin Gastroenterol. 2000; 31(4):309-13.

    41. Pandey M, Sood BP, Shukla RC, Aryya NC, Singh S, Shukla VK. Carcinoma of the gallbladder: role of sonography in diagnosis and staging. J Clin Ultrasound. 2000; 28(5): 227-32.

    42. Pandey M, Singh SP, Behere PB, Roy SK, Singh S, Shukla VK. Quality of life in patients with early and advanced carcinoma of the breast. Eur J Surg Oncol. 2000; 26(1): 20-4.

    43. Chaturvedi S, Singh S, Khanna HD, Khanna S, Khanna R. Cellular DNA contact and its correlation with histopathological prognostic parameters in carcinoma of the breast. Indian J Pathol Microbiol. 1998; 41(3): 337-42.

    44. Shukla VK, Prakash A, Tripathi BD, Reddy DC, Singh S. Biliary heavy metal concentrations in carcinoma of the gall bladder: case-control study. Br Med J. 1998; 317(7168): 1288-9.

    45. Khanna HD, Singh S, Agrawal G, Khanna R, Singh LP, Khanna R, Khanna S. Intra nuclear estrogen receptor status and its clinicopathological correlation in breast cancer patients. Cancer Biochem Biophys. 1996; 15(3): 141-9.