| || Hippocampal Structure, Function, and Malfunction in Temporal Lobe Epilepsy |
The mammalian hippocampal formation subserves normal learning and memory, but when an injury to the temporal lobe occurs, the hippocampus can become a source of devastating epileptic seizures that cannot currently be stopped. Our lab is interested in understanding how and why an injured hippocampus becomes spontaneously and abnormally active, and we develop animal models that replicate the human neurological disorder.
Currently, we use chronically implanted electrodes that enable us to produce a controlled injury and then to assess hippocampal cell population hyperexcitability and epilepsy onset. In addition to in vivo electrophysiology, we use histological and immunocytochemical methods to characterize the pathology and determine how it is related to the epileptic state. Laboratory Members
Robert S. Sloviter, Ph.D.
Argyle V. Bumanglag, Ph.D.
Eugene Chun, BS
Research Key Words: Hippocampus, Dentate Gyrus, Epilepsy, Status Epilepticus, Traumatic Head Injury, In Vivo Electrophysiology, Anatomy and Immunocytochemistry
Click here to view selected publications.