| | Ion Channels and Neurological Disorders The goal of Dr. Xiong's research is to understand the role of certain ion channels and membrane receptors in neurological disorders. Brain ischemia, for example, initiates various biochemical changes such as increased glutamate release, brain acidosis, and oxidative stress. These changes favor the activation of various membrane receptors and ion channels. Activation of these channels contributes either directly or indirectly to intracellular ion disturbance (e.g. calcium overload) resulting in neuronal injury. The studies in Dr. Xiong’s laboratory focus on several calcium-permeable ion channels, including glutamate receptor-gated channels, acid-sensing ion channels (ASICs), and TRPM7 channels. Using a combination of patch-clamp recording, fluorescence calcium imaging, biochemistry and molecular biology techniques, in vitro and in vivo models of neurological disorders, Dr. Xiong’s team investigates the electrophysiological properties, pharmacological profiles, and the pathological roles of these channels in neuronal injury.
[read more] Laboratory Members Zhigang Xiong, MD, PhD, Principal Investigator
Koichi Inoue, MD, PhD, Assistant Professor
Tiandong Leng, MD, PhD, Postdoctoral Fellow
Mingli Liu, PhD, Postdoctoral Fellow
Huali Li, MD, PhD, Visiting Scholar
Huaiqiang Hu, MD, PhD, Visiting Scholar
Zhao Zeng, PhD Candidate, Visiting Scholar
Zaven O’Bryant, PhD Student
KaNesha Gillyard, Undergraduate Student Click here to view selected publications. Editorial Responsibility International Journal of Physiology Pathophysiology and Pharmacology, Editor-in-Chief
Neurological Research, Editorial Board Member
International Journal of Experimental and Clinical Medicine, Editorial Board Member
CNS Neurosciences & Therapeutics, Editorial Board Member
American Journal of Translational Research, Editorial Board Member |