|Contact Information |
|Phone: (404) 752-1712 |
Fax: (404) 752-1164
|Research Interests |
Research Interest My general interest is in the area or receptor pharmacology and its relationship to cardiovascular function. My major interests are in the properties, regulation, metabolism and molecular mechanisms of the adenosine nucleoside transporter in pathophysio-logical processes of the cardiovascular system. My specific interest is to understand the mechanisms of neuroprotection by adenosine and other trophic factors in the pre-morbid and morbid state in conditions such as stroke, glaucoma, hypertension and atherosclerosis. The biochemical and pharmacological characterization of the nucleoside transporters employing radioligand binding approaches have facilitated their pharmacological analysis in many tissues and cultured cell lines as well as the targeted screening of drug candidates that they potentially interact with. Currently, I am involved in the characterization of the neuroprotective effects of neuregulins, a family of multipotent epidermal growth factor (EGF)-like proteins that promote growth, differentiation, and survival during development, in the pathogenesis of atherosclerosis.
Dr. Evan Williams is an Associate Professor of Pharmacology and Course Director of the Medical Pharmacology and Toxicology course. He received his Ph.D. degree in Pharmacology from Howard University School of Medicine in Washington, D.C. Upon graduation, he went to the National Institutes of Health on a three year Fogarty International Fellowship award for postdoctoral research training in the laboratories of Drs. John W. Daly and Phil Skolnick at the NIDDKD, where he made significant contributions to the elucidation of the mechanism of action of the group of drugs known as the benzodiazepines.
Dr. Williams then proceeded to the University of Alberta in Edmonton, Alberta, Canada where he continued his postdoctoral training on an Alberta Heritage Foundation for Medical Research Fellowship award in the laboratory of Dr. Alexander Clanachan in the Department of Pharmacology. In this laboratory, he pioneered the identification of binding sites for adenosine nucleoside transporters in the cardiovascular system. Dr. Williams became a faculty member at Morehouse School of Medicine in 1984. In addition to his research activities, Dr Williams participates in the teaching of the Medical Pharmacology Course and serves in several institutional standing committees.
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