|Contact Information |
|Phone: (404) 752-1714 |
Fax: (404) 752-1164
|Research Interests |
Our research interests are focused on evaluating central and peripheral factors involved in the development and maintenance of genetic and salt-induced hypertension. More specifically, we are involved in defining the mechanisms associated with the regulation of cardiovascular and hemodynamic functions in association with the release of various neuromodulators and catecholamines. We have gained in roads to a better understanding of the role of RAAS in the vascular maladaptations and end organ damage associated with salt-induced hypertension. Our understanding of the role of various RAAS inhibitors and blockers of the synthesis of cholesterol (statins) has been helpful in understanding the roles of these agents in reducing morbidity and mortality in patients. We intend to extend these studies by exploring the molecular and genomic factors associated with salt-induced hypertension.
We are also interested in studying the influence of microgravity on cardiovascular and neuroendocrine responses, using a tail-suspended rat model (30o head down tilt) with "unloaded" hindlimbs. Post-flight orthostatic intolerance is a dramatic physiologic consequence of human adaptation to microgravity made inappropriate by a sudden return to normal gravity. The loss of appropriate cardiovascular reflexes contributes to the cardiovascular deconditioning (hypotension and tachycardia), but the exact mechanisms remain unclear. To further understand the above phenomenon and to develop potential countermeasures, we have investigated the role of dietary salt/salt-sensitivity in combination with other compounds (i.e. angiotensin-(1-7) antagonists, adrenergic agonists, endothelium-dependent contracting factors, such as endothelin, and nitric oxide antagonists). The findings in our laboratory indicate that increased production and/or release of endothelium-derived relaxing factors (i.e. nitric oxide and prostacyclin) contribute to post-suspension hypotension in rats as is suspected to be the case in astronauts. We were among the first to show that reduction in blood pressure following simulated microgravity (tail suspension) may be due to an increase in nitric oxide production.
Undergraduate students in my laboratory have been very active and have participated in most of the research protocols in our laboratory. For example, Garrett Mann, a student at Morehouse College, has presented at local and national meetings on data related to our current funding. At the ABRCMS meeting in Dallas, Texas, Garrett presented the “Effect of Eplerenone on Salt-Induced Hypertension in Dahl Salt-Sensitive Rats” and was awarded top prize in his category. The research activities in our laboratory have been supported in part by NASA, NSBRI, MBRS and MERCK.
Mohamed A. Bayorh, Ph.D. is a Professor and Interim Chair of Pharmacology/Toxicology. Dr. Bayorh attended Bowie State University in Maryland from 1973-75 and received a B.S. (Honors) in Biology. In 1975, he enrolled at Howard University where he received a Howard Trustee Fellowship during his first year and a Sierra Leone Government Scholarship for 4 years. Dr. Bayorh graduated from Howard University in the top 1% of his class in 1980 with a Ph.D. in Pharmacology. He then went to the National Institutes of Health to pursue post-doctoral training in the Nobel Prize laboratory of Dr. Julius Axelrod. Dr. Bayorh worked directly with the Chief of the laboratory Dr. Irwin Kopin in the laboratory of Clinical Sciences for 3 years before joining the Uniformed Services University of the Health Sciences as a Research Assistant Professor for a year.
Dr. Bayorh was recruited by Morehouse School Of Medicine in 1984. Since joining MSM as an Assistant Professor, he has moved up the ranks to a full Professor of Pharmacology and has served as the Interim Chair of the department for the past 3 years. At MSM, Dr. Bayorh has significantly contributed to the development of the medical school both in teaching medical students and in attracting research funds. He has contributed to bringing million of dollars to the school in research funds. Dr. Bayorh’s major areas of research at Morehouse School Of Medicine are in Drugs of Abuse and Cardiovascular Research. His recent focus has been mostly in salt-induced hypertension and in the role of eicosanoids in health. He was the first to introduce the Dahl rat model at MSM to aid in evaluating the hypertensive condition that is akin to that observed in African Americans. Dr. Bayorh has significantly contributed in the scientific knowledge base by having published over 80 articles in peer-reviewed scientific journals. He serves a reviewer for several scientific journals including the Journal of Hypertension where he serves as an adhoc reviewer. Dr. Bayorh has served as a member of the Cardiovascular Alteration Team of the National Space Biomedical Research Institute and currently serves on grant review committees for the NIH/NCRR, and Canadian Space Research Council. He is married with two children.
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