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  • GEBS 500 - Introduction to Epidemiology (3 credit hours; MSCR core)
    This course provides students with knowledge of patterns of disease occurrence in human populations and factors that influence these patterns. This course is designed to enable students to identify and use systematic procedures that are helpful in determining epidemiological relationships. Principles and methods of epidemiologic investigation, both of infectious and non-infectious diseases are discussed. Prerequisite: MCR 512 Fundamentals of Biostatistics.
    Course Director: Lee Caplan, PhD

    GEBS 501 – Medical Informatics (2 credit hours; MSCR core)
    The course will address using data from clinical information systems in performing clinical research including the strengths and limitations of these data. Topics include: overview of medical informatics, discussion of the nature of computer-based data including medical vocabularies, large databases, the web, and confidentiality-related issues.
    Course Director: Jerome Carter, MD

    GEBS 502 –Principles of Clinical Research (2 credit hours; MSCR core)
    This course is offered in collaboration with NIH, and delivered through video-conferencing. This course provides an overview and introduction to the various types of clinical research including Patient-oriented research, epidemiology, behavioral sciences and health services research, and introduction to evidence-based medicine for clinical researchers. The course introduces protocol design, mentoring development, and gathering of evidence, including decision analysis.
    Course Director: Alexander Quarshie, MD, MS

    GEBS 503-508 – Seminar in Biomedical Sciences I-VI (1 credit hour each; PhD, MSBR, and MSBT core)
    Students attend a minimum of 6 research seminars per semester. Graduate faculty signature on seminar form and on 250-word summary of each seminar required for credit.
    Course Director: Douglas F. Paulsen, PhD.

    GEBS 509 and 510 Biomedical Science Presentation I and II (1 credit hour each; PhD, MSBR, and MSBT core)
    The objective of these courses is to provide students with experience organizing and delivering a research seminar. Ph.D. students are required to complete two qualified presentations, and M.S. students one presentation during their tenure as graduate students. Qualified presentations include: One student research day platform presentation, any one-hour seminar advertised to the MSM community and open to the public., and a platform or poster presentation at a national scientific conference accompanied by a first-author published abstract. This requirement is explicitly in addition to the student’s dissertation proposal and defense presentations. Prerequisite: Enrollment at MSM.
    Course Director: Doug Paulsen, PhD
    Letter Grade. Offered annually, Fall, Spring.

    GEBS 511 – Clinical Research Seminar (2 credit hours; MSCR core)
    This course involves presentation, review and critique of ongoing clinical research. Presentations would be by internal and guest faculty and students.
    Offered Annually.

    GEBS 513 and 514 Laboratory Rotation I and II (1 credit hour each; PhD, MSBR, and MSBT core)
    The objective of these rotations is to provide students with experiences that will allow them to make an informed choice with respect to the focus of their research or technical apprenticeship and their research or technical advisor. Two 8-week rotations are required of each student and must be carried out in a laboratory in which the student has not previously worked. Rotation sites may include laboratories of MSM graduate faculty, or off-campus sites with the permission of the GEBS Committee. These rotations must be completed before the beginning of the PhD student’s second academic year and by the middle of the second semester for the MS students. Prerequisite: Enrollment at MSM.
    Course Director: Doug Paulsen, PhD
    Pass/Fail. Offered annually, Fall, Spring, Summer

    GEBS 516 – Mentored Research Project (12 credit hours; MSCR core)
    This course provides an opportunity for students to synthesize and integrate the knowledge base and competencies acquired in course work and practicum and demonstrate this achievement through writing and presenting a grant proposal, mentoring or journal manuscript.
    Course Director: Alexander Quarshie, MD, MS

    GEBS 517 Graduate Biochemistry (3 credit hours; PhD, MSBR, and MSBT Core Module 1)
    This course introduces biochemical principles, molecular biology, and metabolism in a lecture and group discussion format. the
    Prerequisite: Enrollment at MSM
    Course Director: Gary Sanford, PhD
    Letter Grade. Offered annually, Fall.

    GEBS 517L Biochemistry Laboratory (3 credit hours; PhD, MSBR, and MSBT Core Module 1 Lab)
    This course introduces students to theoretical and practical issues in the isolation and manipulation of DNA, RNA and protein from eukaryotic cells. Technical instruction in the laboratory will be supplemented with lectures on innovative approaches to genomic and proteomic investigation. The course will provide a basis for using these powerful molecular methodologies to solve complex biomedical research problems.
    Prerequisite: Enrollment at MSM
    Course Director: Gary Sanford, Ph.D.
    Letter Grade. Offered annually, Fall.

    GEBS 518 Fundamentals of Professional Science (FPS) I (3 credit hours; PhD, MSBR, and MSBT Core Module 1)
    The first module of the FPS sequence covers many aspects of scientific integrity and professionalism, and introduces research opportunities at the institution. It also introduces critical thinking, scientific writing and organization and analysis of research papers.
    Prerequisite: Enrollment at MSM.
    Coordinator: Doug Paulsen, PhD
    Scientific Integrity Component Director: Jonathan Stiles, PhD
    Critical Thinking Component Directors: Gale Newman, Gary Sanford, Jacqueline Hibbert.
    Letter Grade. Offered annually, Fall.

    GEBS 519 Fundamentals of Professional Science II (1 credit hour; PhD, MSBR, and MSBT Core Module 2)
    The second FPS module continues coverage scientific writing through an exercise of writing and critiquing a collaborative research proposal.
    Prerequisite: Enrollment at MSM
    Sequence Coordinator: Doug Paulsen, PhD
    Grant-writing Course Directors: Sandra Harris-Hooker, PhD and Gianluca Tosini, PhD
    Letter Grade. Offered annually, Fall.

    GEBS 520 – Analysis of Frequency Data (3 credit hours; MSCR core)
    This course is intended to provide a more detailed approach to the analysis of categorical data in clinical and translational research. Tests and measure of association for contingency table analysis; partitioning chi-square; the odds ratio, comparative trials; analysis of categorical data with matched samples; combining evidence from contingency tables; effects and controls of misclassification errors, multi-way contingency tables.
    Prerequisite: MCR 512 Fundamentals of Biostatistics
    Course Director: Ahmad Al-Mahmoud, PhD.

    GEBS 521 Cells and Tissues: GEBS Core Sequence, Module 2 (3 credit hours; PhD, MSBR, MSBT, and MSCR Core Module)
    This course surveys cell and tissue structure and function. It provides a review of the methods and basic concepts of cell biology and histology as a foundation for biomedical research.
    Prerequisite: Enrollment at MSM
    Sequence Director: Gale Newman, PhD
    Course Director: Brenda Klement, PhD
    Letter Grade. Offered annually, Fall.

    GEBS 521L Cells and Tissues Laboratory: (3 credit hours; PhD, MSBR, MSBT, and MSCR Core Module Lab)
    This course includes demonstrations and hands-on experience with studies of cell and tissue structure. Prepared slides will be used to introduce basic concepts. Students will complete independent projects involving histological examination of an organ of their choice. Prerequisite: Enrollment at MSM.
    Sequence Director: Gale Newman, PhD
    Course Directors: Brenda Klement, PhD; Doug Paulsen, Ph.D.; Jacqueline Powell, Ph.D.
    Letter Grade. Offered annually, Fall.

    GEBS 522 - Clinical Trials (2 credit hours; MSCR core)
    Principles for the design and conduct of clinical trials are discussed. Emphasis will be given to protocol preparation, randomization, sample size, trial monitoring, ethical issues and data analysis.
    Prerequisite: MCR 512 Fundamentals of Biostatistics or permission of instructor
    Course Director: Jose Binongo, PhD (Emory University)

    GEBS 523 - Scientific Writing and Communication (3 credit hours; MSCR core)
    The objective of this course are to develop: 1) the ability to evaluate a variety of funding sources, write concept papers and letters of intent in biomedical sciences, 2) an approach to writing a competitive research proposal, 3) an understanding of the NIH review process. The course provides an overview of these processes in a series of didactic discussions and take-home assignments. Students are required to design a study for specific disease and prepare a scientific protocol and a grant application using Public Health Service Form 398 including the development of a consent form and budget. Emphasis will be placed on grantsmanship and scientific writing, the Institutional Review Board and NIH review process.
    Course Director: Brenda Hayes, DSW, MPH

    GEBS 524 - Fundamentals of Biostatistics (3 credit hours; PhD, MSBR, MSBT, and MSCR core)
    This course introduces various statistical methods used in basic, clinical and translational research and public health management. Students are trained in data analysis theory, data management and interpretation of results using standard statistical packages. Topics include: Probability distributions and conditional probability; descriptive statistics; statistical inference; parametric and nonparametric procedures; regression and correlation methods; repeated measures; survival analysis.
    Course Director: Ahmad Al-Mahmoud, PhD

    GEBS 525 Laboratory Rotation III (1 credit hour; Elective)
    This is an elective lab rotation. Students may receive credit for a maximum of 3 lab rotations (2 core and 1 elective). The objective of the core rotations is to help students make an informed choice with respect to their research focus their major research advisor. This 8-week elective rotation requires students to work in a laboratory other than that of the major advisor to develop additional skills and experience that may be helpful in their dissertation project. Rotation sites may include laboratories of MSM graduate faculty, or off-campus sites with the permission of the GEBS Committee.
    Prerequisites: Successful completion of PhD core curriculum, approval of advisor, and permission of the course director.
    Course Director: Doug Paulsen, PhD
    Pass/Fail Offered annually Fall, Spring, Summer

    GEBS 526 – Fundamentals of Professional Science III (1 credit hours; PhD, MSBR, and MSBT Core Module 3)
    The third FPS module includes sessions scheduled to introduce various career opportunities in professional science, discussions with various visiting researchers, and attendance and evaluation of Curtis Parker Student Research Day activities.
    Prerequisite: Enrollment at MSM
    Sequence Coordinator: Doug Paulsen, PhD
    Letter Grade. Offered annually, Spring

    GEBS 527 Fundamentals of Professional Science IV (1 credit hour; PhD, MSBR, and MSBT Core Module 4)
    The fourth FPS module continues coverage of career opportunities and interactions with visiting researchers.Additional sessions may cover patent and intellectual property considerations for scientists.
    Prerequisite: Enrollment at MSM
    Sequence Coordinator: Doug Paulsen, PhD
    Letter Grade. Offered annually, Spring

    GEBS 528 Biomedical Genetics (3 credit hours; PhD Core Module 4, MSBR, and MSBT Elective)
    This course covers chromosome and gene structure and function, molecular and population genetics, model organisms for genetic studies, as well as molecular pathology, disease susceptibility, and genetic testing. Students will explore the relationships between animal models and human biology and disease, as well as the role of human variation in experimental design, and the value of including all genders, ages, and ethnicities in their studies.
    Prerequisite: Enrollment at MSM.
    Sequence and Course Director: Gale Newman, PhD
    Letter Grade. Offered annually, Fall.

    GEBS 528L Biomedical Genetics Laboratory (3 credit hours; PhD Core Module 4, MSBR, and MSBT Elective)
    This course may include demonstrations, hands-on exercises, and analysis of genetic laboratory methods and their proper applications to accompany and reinforce material covered in lecture.
    Prerequisite: Enrollment at MSM
    Sequence and Course Director: Gale Newman, PhD
    Letter Grade. Offered annually, Spring

    GEBS 529 Organs and Systems (4 credit hours; PhD Core Module 3, MSBR, and MSBT Elective)
    This course covers structural and functional integration, from the cellular to organ system level, for the Endocrine and Reproductive, Nervous, Cardiovascular, Immune/ Lymphoid, Respiratory, and Urinary Systems.
    Prerequisite: Enrollment at MSM
    Sequence Director: Gale Newman, PhD
    Course Directors: Jacqueline Powell, Ph.D.; Brenda Klement, Ph.D.: Doug Paulsen, Ph.D
    Letter Grade. Offered annually, Spring

    GEBS 529L Organs and Systems Laboratory (3 credit hours; PhD Core Module 3, MSBR, and MSBT Elective)
    This course includes demonstrations, hands-on exercises, prepared slides, and ongoing projects on disease processes affecting the organs chosen for PHD 521L projects.
    Prerequisite: Enrollment at MSM
    Sequence Director: Gale Newman, PhD
    Course Director: Jacqueline Powell, Ph.D. Brenda Klement, Ph.D., Doug Paulsen, PhD
    Letter Grade. Offered annually, Spring

    GEBS 530 - Health Services Research (2 credit hours; MSCR core)
    This course introduces key concepts in health services research such as understanding the multiple dimensions of health status and conceptual basis of measuring health status and outcomes, includes review and evaluation of the strengths and weaknesses of common measures, formalization of research questions and appropriate design of methodology including sample selection, measurement, data collection and statistical analysis.
    Prerequisite: Permission
    Course Director: Eugene Oddone, MD, PhD (Duke University)

    GEBS 531 – Clinical Laboratory Rotation (2 credit hours; MSCR core)
    This course is designed to provide trainees with hands-on exposure to existing core units at the Clinical Research Center and how they support clinical and translational research. These cores are - Noninvasive Cardiovascular and Hemodynamics, Analytical and Protein Profiling, Bionutrition, Nursing, Recruitment/Retention, Biostatistical and Data Management, Clinical Trials, Research Subject Advocate and Data Safety Monitoring Cores.
    Course Director: Alexander Quarshie, MD, MS

    GEBS 532 – Clinical Research in Health Disparities / Community Engagement (1 credit hour; MSCR core)
    This course introduces key issues in health disparities and community engaged research. Focus is on ways to assess and address health disparities, with an emphasis on inner-city and African American populations. Approaches to community engagement and community-centered research are addressed.

    GEBS 600 Advanced Molecular Biology (3 credit hours; Elective)
    The objective of this course is to provide graduate students with an understanding of contemporary molecular biology concepts, their application to basic biomedical research and to disease processes. Faculty members present an overview of areas that may include DNA replication/repair, transcription and chromatin remodeling, post-translational modification, protein stability and folding, along with selected signal transduction pathways. The format includes direct student participation in which each student is required to present assigned research papers in PowerPoint, as well as to submit summary reports on discussed papers. A final written exam is required in which each student must write an abstract of a research paper. The abstract must reflect good organization, clarity, conciseness and the use of correct grammar. In addition to an in-depth review of molecular biology concepts, students gain experience in seminar presentation and writing summaries.
    Prerequisites: Successful completion of core curriculum. Permission of the course director is required.
    Course Director: Deborah Lyn, PhD
    Letter Grade. Offered annually, Fall or Spring

    GEBS 610 Fundamentals of Professional Science V (2 credit hours; PhD core)
    The fifth FPS module continues instruction in proposal writing in a practical way through development of applications for predoctoral fellowship support.  Each student will develop and submit a predoctoral fellowship application for extramural funding.
    Prerequisite: Enrollment at MSM, satisfactory completion of first year core curriculum
    Sequence Coordinator: Doug Paulsen, PhD
    Grant Writing Course Directors: Sandra Harris-Hooker, PhD and Gianluca Tosini, PhD
    Core course (required) Letter Grade. Offered annually, Fall

    GEBS 625-630 Technical Apprenticeship, Minimum of four 8-week internships, 4.5 credit hours each; MSBT core)
    These are four internships involving full-time work in service laboratories.  Three of these must be in MSM core research service laboratories. The fourth, or even a fifth may be offsite at another institution or company. Each apprenticeship must culminate in a written summary including detailed experimental protocols.
    Prerequisite: Completion of MSBT Core curriculum, Approval of Technical Advisor, host laboratory supervisor, and course director.
    Course Director: Doug Paulsen, PhD
    Pass/Fail Offered annually, Fall, Spring

    GEBS 651- Introduction to Pathology (3 credit hours)
    This course covers the general principles of pathology as presented in the first unit of the medical students’ Pathology course (M606). It may include additional discussion sessions and/or essay exams for graduate students.  Topical material includes general processes common to many diseases, such as the reactions of cells and tissues to injury and neoplasia, and disorders that are not necessarily organ specific, such as infections nutritional diseases, immune diseases, and environmental disorders. Specific attention is paid to causes, pathogenic mechanisms, morphological and functional effects associated with the reactions. Teaching methods include lectures, laboratory discussions of simulated cases utilizing fixed gross specimens, histology preparations, photomicrographs, and other graphic material to illustrate morphological and functional changes in disease and to reinforce the lecture material. The clinical case simulations and discussions relate the disease pathogenesis, morphology and functional disturbances to clinical signs and symptoms that occur in an affected patient.
    Prerequisites: Successful completion of PhD core curriculum, approval of advisor, and permission of the course director.
    Course Director: Marjorie Smith, MD
    Letter Grade.  Offered annually, Fall

    GEBS 653 Concepts of Immunology (3 credit hours)
    This course teaches graduate students concepts and methodologies used in immunological research. Graduate students will attend Immunology sessions for medical students. In addition, graduate students meet for indepth discussion of experimental design and methods to measure immune responses.
    Prerequisites: Successful completion of PhD core curriculum, approval of advisor, and permission of the course director.
    Course Director: Gale Newman, PhD
    Letter Grade. Offered annually, Fall

    GEBS 654 – Medical Bacteriology (4 credit hours)
    This section of the Medical Microbiology and Immunology course covers bacterial structure, metabolism, and genetics, as well as the pathogenic bacteria associated with human infection. Additional graduate sessions include journal clubs and lectures on experimental concepts in medical microbiology.)
    Prerequisites: Successful completion of PhD core curriculum, approval of advisor, and permission of the course director.
    Course Director: Michael Powell, PhD
    Letter Grade. Offered annually, Spring

    GEBS 656 – Medical Virology (2 credit hours)
    This course concentrates on the viruses of medical importance. It provides a basic understanding of the mechanisms of replication, pathogenesis, diagnosis, and treatment of viral diseases. One lecture a week is devoted to a more detailed understanding of the molecular aspects of viral replication. Grading is based on a series of quizzes and an overall written exam. In addition, students will prepare an in-class oral presentation of a current research topic.
    Prerequisites: Successful completion of PhD core curriculum, approval of advisor, and permission of the course director.
    Course Director: Michael Powell, PhD
    Letter Grade. Offered annually, Spring

    GEBS 657- Principles of Pharmacology (1 credit hour)
    This course covers the general principles of pharmacology: Pharmacodynamics and pharmacokinetics. In this first unit of the medical student’s Pharmacology and Toxicology course (M603), students are introduced to the effects of drugs on the body and the effects of the body on drugs.
    Prerequisites: Successful completion of PhD core curriculum, approval of advisor, and permission of the course director.
    Course Director: Evan Williams, PhD
    Letter Grade. Offered annually, Fall

    GEBS 675 -Thesis Research (Maximum 9 credit hours per semester, Minimum of 12 credit hours required for graduation; MSBR core)
    This course reflects the student’s efforts on his or her thesis research. In each case, the number of hours, expectations for progress, and the grade given are to be determined by the student’s research advisor and dissertation committee.
    Prerequisite: Admission to MS Candidacy, Approval of research advisor and course director.
    Course Director: Doug Paulsen, PhD
    Pass/Fail Offered annually, Fall, Spring

    GEBS 700 Cell and Developmental Biology (3 credit hours)
    This course will introduce students to the dynamics of embryonic development. Lectures, student presentations, and discussions will familiarize students with one of the most incredible processes in the living world: embryonic development. Lectures will focus on a variety of well-characterized developmental models and processes.
    Prerequisites: Successful completion of PhD core curriculum, approval of advisor, and permission of the course director.
    Course Director: Leonard Anderson, PhD
    Letter Grade. Offered even years, Spring

    GEBS 702 Advances in Reproductive Biology (3 credit hours)
    This course involves required classroom sessions and seminar attendance.  Selected areas will be reviewed by the Faculty and relevant research papers will be assigned for student presentation and class discussion. Topics will include an introduction to the embryology of gonadal differentiation, and comprehensive reviews of the published literature in genetic, molecular, endocrine, and neuroendocrine research; especially as they impact the diagnosis and treatment of male and female reproductive pathology.
    Prerequisites: Successful completion of PhD core curriculum, approval of advisor, and permission of the course director.
    Course Director: Kelwyn Thomas, PhD
    Letter Grade. Offered even years, Spring

    GEBS 704 Cell and Molecular Neurobiology (4 credit hours)
    The course covers the major advancements in modern neuroscience. Lectures will discuss cellular and molecular mechanisms of neurodevelopment, neuronal function and glial differentiation. In addition, the molecular and functional organization of sensory, motor and regulatory systems will be presented. Ligand and voltage gated signal transduction, learning and memory, neuroendocrine regulation and behavior and neural control of circadian rhythm will also be covered. Additional journal club sessions may be included.
    Prerequisites: Successful completion of PhD core curriculum, approval of advisor, and permission of the course director.
    Course Director: Gianluca Tosini, PhD
    Letter Grade. Offered annually, Spring

    GEBS 706 Molecular Mechanisms in Cardiovascular Science (3 credit hours)
    The course will provide students with an understanding of the cellular, molecular, and biochemical mechanisms involved in the field of cardiovascular science. Special emphasis will be placed on reading and interpreting the original literature, integrating information to develop new approaches, and organizing research literature to develop an understanding of the complex issues in cardiovascular science.
    Prerequisites: Successful completion of PhD core curriculum, approval of advisor, and permission of the course director.
    Course Director: Leonard Anderson, PhD
    Letter Grade.  Offered annually, Spring

    GEBS 708 Cancer Biology (3 credit hours)
    This course is designed to provide the background for understanding a number of genetic, cellular, molecular, and biochemical mechanisms involve in different aspects of cancer biochemistry. This course will also emphasize reading and interpreting the original literature, integrating information to develop new approaches, and organizing research literature to develop an understanding of a complex area. Active participation and targeted reports on topics covered in the reading will be emphasized. In the end, students should have an improved understanding of cellular, molecular and biochemical mechanisms involved in the field of cancer biology.
    Course Director: Gary Sanford, PhD
    Letter Grade offered annually in the spring

    GEBS 749 Supervised Research (Maximum 8 credit hours per semester)
    This course reflects supervised research efforts beyond the required laboratory rotations, but before achieving degree candidacy and beginning dissertation research. The number of hours, expectations for progress, and grade are to be determined by the student’s research advisor (and dissertation committee, if selected). Credits awarded for this course do not count toward the minimum requirement for elective credit.
    Prerequisites: Successful completion of the core curriculum, approval of advisor and lab director, and permission of the course director.
    Course Director: Doug Paulsen, PhD
    Pass/Fail. Offered annually, Fall, Spring

    GEBS 800 Dissertation Research (Maximum 9 credit hours per semester, Minimum of 25 credit hours required for graduation; PhD core)
    This course reflects the student’s efforts on his or her dissertation research.  In each case, the number of hours, expectations for progress, and the grade given are to be determined by the student’s research advisor and dissertation committee.
    Prerequisite: Admission to PhD Candidacy, Approval of research advisor and course director.
    Course Director: Doug Paulsen, PhD
    Pass/Fail Offered annually, Fall, Spring.