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  • CLAR Policies and Procedures

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  • CLAR Animal Facility Access Policy

    CLAR animal rooms are on a 12 hour on/12 hour off light/dark cycle. The lights automatically turn on at 7:00 AM and off at 7:00 PM or 6:00 AM – 6:00 PM, depending on Daylight Savings Time, with a few exceptions. Please do not manually manipulate the lights within the CLAR Animal Facility.

    • Work conducted in the animal rooms should not begin before 7:00 AM and should end before 7:00 PM or 6:00 AM – 6:00 PM, depending on Daylight Savings Time. If you need access to the animal facility during dark hours, a written request is required.
    • For reasons of security, public health and animal health, anyone wishing to enter the animal facilities must have an authorized MSM swipe badge issued in their name. Records of their credentials and swipe badge authorization must be on file with the Center for Laboratory Animal Resources Administrative Office (404-752-1724).
    • Only individuals listed on an approved MSM-IACUC protocol can handle research animals under the care of the CLAR Animal Facility.
    • New personnel may not access CLAR Animal Facilities until they have attended the CLAR Orientation session, submitted all required documentation to the CLAR Admin office and a Badge Access Approval form has been authorized by CLAR Administrative Staff and submitted to Public Safety.
    • Visitors to the CLAR Animal Facility must be accompanied by their faculty sponsor or a member of the Center for Laboratory Animal Resources staff. The visit should be approved, in advance, by the Director of CLAR Operations.
    • Persons less than 18 years old are prohibited from entering the facilities at all times.
    • Please do not allow unauthorized individuals to use a swipe badge issued in someone else's name or allow them to handle research animals.
    • The CLAR Administrative Office cannot be used as a means to enter or leave the Animal Facility.
    • Any individual working in the CLAR Animal Facility must adhere to all Standard Operating Procedures.

    Violations will result in the following actions: 

    1st Offense - The principal investigator responsible for the violator will be notified. An infraction letter will be issued and must be signed by the principal investigator and the violator to avoid a temporary loss of CLAR Facility Access privileges.

    2nd Offense - Temporary loss of CLAR Animal Facility access until CLAR Orientation is repeated by the violator. An infraction letter will be issued and must be signed by the principal investigator and the violator.

    3rd Offense - Your CLAR Facility Access will be rescinded. The principal investigator and the violator will have to attend CLAR Orientation and meet with the CLAR Admin Staff before access is granted again.

    CLAR Visitor Policy

    • For reasons of security, public health and animal health, anyone wishing to visit the animal facilities must register with the Center for Laboratory Animal Resources office (404-752-1724).
    • Visitors to the CLAR Animal Facility must be accompanied by their faculty sponsor or a member of the Center for Laboratory Animal Resources staff. The visit should be approved, in advance, by the Director of CLAR Operations.
    • Staff access to animal facilities is limited to persons whose assigned duties require that they enter the facilities.

    CLAR Animal Ordering Policy as of January 1, 2013

    1. All CLAR Purchase Request Forms for Research Animals must include the following information:

      The date the order is being placed, the date the animals are required, the approved protocol number the animals are being ordered under, the P.O. #, the vendor chosen, the name of the person requesting the order, the principal investigator's name, your department name, your extension, the species to be ordered, the sex of the animals, the strain or stock number of the animal, quantity, and a weight or age specification.

      If your Purchase Request Form for Research Animals is missing any of the above information, the order will be returned to you and will not be placed until the missing information is provided. CLAR cannot be held responsible for the submission of incomplete animal orders.

    2. All CLAR Purchase Request Forms for Research Animals must be accompanied by an approved purchase order (for AUC PIs) or an approved requisition (for MSM PIs) to cover subsequent per diem charges for the period of time the animals will be housed in CLAR facilities.
    3. No animal orders will be placed if your PO is not on file with CLAR. In addition, if you do not have available funds on your PO at the time you submit your order, the order will not be placed until the funds are available.
    4. CLAR Animal Facility personnel will contact you at the extension listed on your animal order once the animals arrive.
    5. All outstanding CLAR per diem charges must be cleared before placing additional orders for research animals.

    CLAR Per Diem Policy as of January 1, 2013

    1. All CLAR Purchase Request Forms for Research Animals must be accompanied by an approved purchase order (for AUC PI's) or an approved requisition (for MSM PI's) to cover subsequent Per Diem charges for the period of time the animals will be housed in CLAR facilities.
    2. For long term studies of two months or more, the AUC blanket purchase order or MSM requisition need not cover the entire anticipated housing period. However, in agreement with CLAR, requisitions should be for a sufficient dollar amount so that there is time to generate a new purchase order before the previous one is exhausted. As funds decrease, the investigator may issue a new Per Diem purchase order or MSM requisition or the investigator can notify CLAR that the animals may be euthanized by a specified date or transferred to CLAR for reassignment to another protocol or for animal training purposes.
    3. Your monthly Per Diem invoice will reflect the current total amount available for use on your account. Please pay close attention to this information to avoid your account reaching a PAST DUE status. If your account reaches a PAST DUE status, you will receive a Past Due Memo detailing the current total amount due. These memos should be addressed immediately by clearing the total amount due on your account.
    4. CLAR cannot continue to, breed, order additional animals or house additional animals for investigators with PAST DUE accounts.

    Policy for Reserving Space in Biocontainment Cages and Quarantine

    There has been an increasing need for quarantine and biocontainment caging of mice being received by investigators during this year. Because of the expense of these cages and their need to be replaced frequently, there is often a shortage of biocontainment cages. So as to minimize the delay in the shipment of mice, investigators requiring use of the biocontainment cages and quarantine facilities must notify the Center for Laboratory Animal Resources (CLAR) in advance of their requirements.

    Rather than having an arbitrary time required for notification, investigators are advised to submit their request to CLAR indicating the number of animals being shipped, the duration of the experiment if they are immunodeficient and whether these will be mated for production of genetic progeny. If so, include an estimate of the number of offspring that also must be housed. If cages are not expected to be available, investigators will be put on a waiting list and will be notified of approximate date of cage availability. Animal orders may have to be split, in order to accommodate the needs of as many investigators as possible.

    Here is a list of mice that require the use of biocontainment cages (BCU) and space in quarantine rooms:

    • Severe Combined ImmunoDeficient (SCID) mice are housed in the BCU cages to protect from potential contamination for the duration of the experiments.
    • Nude mice are immunodeficient and are housed in the BCU cages to protect from potential contamination; housed for the duration of experiment.
    • Mice from unapproved sources, usually other institutions and investigators. Housed for two to three months in BCU cages to protect the other colonies from potential contamination; quarantine period varies with the number of cages per shipment.

    Sentinel mice are exposed to all mice in the shipment for seven to eight weeks. One of two sentinels is sacrificed and the serum is sent to an outside lab for testing. The lab may take as long as two weeks to complete the tests.

    Breeding in quarantine is permitted with prior approval and is based upon available space and supplies.

    Entry to quarantine is based on when date forms are received and shipment is approved. When there are more than two cages per shipment, the sentinel cage is changed each day to expose the sentinel to all of the mice in the least amount of time.

    CLAR sentinel breeding colony is housed in BCU cages to protect from potential contamination -indefinitely (12-14 cages are required). These mice are used as sentinels to detect the presence of diseases in the mice housed at CLAR. Serology is conducted on these mice every two to three months to ensure they are free of diseases.