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Peroxisome Proliferator Activated Receptor (PPAR) and Stroke
Namura laboratory studies cerebrovascular functions and their consequences after stroke. He is interested in the effects of fibrates on cerebrovasculature. Fibrates are lipid normalizing drugs that have been used in patients. Fibrates are known to activate PPAR with a higher affinity to the alpha isotype. PPAR alpha is a ligand-dependent transcription factor and plays crucial roles in lipids metabolism. Dr. Namura demonstrated in mice that pretreatment with fibrates improved blood flow in the brain after ischemic stroke, resulting in attenuated brain infarct formation. Such a beneficial effect could not be seen in mice that were deficient in the gene for PPAR alpha. In addition, fibrates showed strong anti-inflammatory actions in the brain subjected to lipopolysaccharide (LPS) injection. These findings suggest that PPAR alpha activation by fibrates may prevent ischemic stroke or improve post-stroke outcomes. The Namura laboratory is currently investigating the cellular and molecular mechanisms that link PPAR alpha activation and such beneficial cerebrovascular effects of fibrates. [Read More]
Shobu Namura, M.D., Ph.D.
Donghui Li, Ph.D.
Fang Du, M.D.
Click here to view a list of Dr. Namura's publications.