• Zhigang Xiong, M.D, Ph.D.

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  • Zhigang Xiong, M.D, Ph.D.

    Professor, Neurobiology
    Senior Scientist, Director of Neurophysiology: Robert S. Dow Neurobiology Laboratories
    Post-Doctoral Fellow: University of Toronto
    PhD, University of Ottawa
    MSc, Sun Yat-Sen University of Medical Science
    MD, Anhui Medical University

    Contact Information

    Phone: (404) 752-8683

    Ion Channels and Neurological Disorders

    The goal of Dr. Xiong's research is to understand the role of certain ion channels and membrane receptors in neurological disorders. Brain ischemia, for example, initiates various biochemical changes such as increased glutamate release, brain acidosis, and oxidative stress. These changes favor the activation of various membrane receptors and ion channels. Activation of these channels contributes either directly or indirectly to intracellular ion disturbance (e.g. calcium overload) resulting in neuronal injury. The studies in Dr. Xiong’s laboratory focus on several calcium-permeable ion channels, including glutamate receptor-gated channels, acid-sensing ion channels (ASICs), and TRPM7 channels. Using a combination of patch-clamp recording, fluorescence calcium imaging, biochemistry and molecular biology techniques, in vitro and in vivo models of neurological disorders, Dr. Xiong’s team investigates the electrophysiological properties, pharmacological profiles, and the pathological roles of these channels in neuronal injury [read more].

    Laboratory Members

    Zhigang Xiong, MD, PhD, Principal Investigator
    Tiandong Leng, MD, PhD, Postdoctoral Fellow
    Musa Hasan, MSc, Research Assistant
    Xuechao Feng, PhD, Visiting Scholar
    Zhao Zeng, PhD candidate, Visiting Scholar
    Cree Robinson, Research Student

    Click here to view selected publications.