Being overweight or obese increases the risk of the development of many diseases such
as diabetes and cardiovascular diseases. The differentiation of preadipocytes is related
to the hyperplasia of adipose tissue. One of the interests in Dr. Liu’s laboratory
is focused on the reduction of adipocyte differentiation in adipose-derived stem cells
(ASCs).
Diabetes is a serious risk factor for ischemic heart disease, which represents a significant
and growing source of morbidity and mortality despite advances in traditional treatments.
Implantation of stem/progenitor cells is an emerging strategy for therapeutic angiogenesis.
Administration of ASCs, which are easily acquired and are lack of surface histocompatibility
antigens, is beneficial for the ischemic heart and limb likely due to a paracrine
function rather than transdifferentiation. Besides secreted soluble growth factors,
cell-released microvesicles/exosomes have been recently described as new mediators
of intercellular communication. Therefore, another interest in Dr. Liu’s laboratory
is to unravel the mechanistic aspects of the proangiogenic effect of ASCs-released
microvesicles in detail. These studies will expand our currently scant knowledge of
the proangiogenic effects of stem cell-released microvesicles and set the basis for
the use of microvesicles as a novel therapeutic approach for ischemic diseases.
Liu D, Lin Y, Kang T, Huang B, Xu W, Garcia-Barrio M, Olatinwo M, Matthews R, Chen YE, Thompson
WE. Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in
3T3-L1 cells
.
PLoS One. 2012;7(3):e34315. doi: 10.1371/journal.pone.0034315. Epub 2012 Mar 30. PMID: 22479600
Gregory-Bass RC, Olatinwo M, Xu W, Matthews R, Stiles JK, Thomas K,
Liu D, Tsang B, Thompson WE. Prohibitin silencing reverses stabilization of mitochondrial
integrity and chemoresistance in ovarian cancer cells by increasing their sensitivity
to apoptosis.
Int J Cancer. 2008 May 1;122(9):1923-30. doi: 10.1002/ijc.23351. PMID: 18183577
Liu D, Hou J, Hu X, Wang X, Xiao Y, Mou Y, De Leon H. Neuronal chemorepellent Slit2 inhibits
vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation.
Circ Res. 2006 Mar 3;98(4):480-9. Epub 2006 Jan 26. PMID: 16439689
Fielding PE, Chau P,
Liu D, Spencer TA, Fielding CJ. Mechanism of platelet-derived growth factor-dependent
caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80.
Biochemistry. 2004 Mar 9;43(9):2578-86. PMID: 14992595
Xiang MX,
Liu D, Chen P, Lu JS. [Effect of PP60c-Src on angiotensin II-induced signal transduction
in rat vascular smooth muscle cells].
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2003 Apr;32(2):126-30. Chinese. PMID: 12734937
Liu D, Lu JS, Yin XL. [Role of pp60c-src in mitogen-activated protein kinase activation
of vascular smooth muscle cells].
Sheng Li Xue Bao. 2000 Dec;52(6):483-6. Chinese. PMID: 11941412
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