Jonathan K. Stiles, PhD Jonathan K. Stiles, PhD Professor & Chair Microbiology, Biochemistry & Immunology jstiles@msm.edu (404) 752-1585 MEB, Room C-352 GRADUATE:

University of Salford

Degree: Doctor of Philosophy, Microbiology



UNDERGRADUATE:

University of Ghana Legon

Degree: Bachelor of Science (Hons), Zoology & Biochemistry

Dr. Jonathan K. Stiles researches the pathogenesis of CNS infections, especially cerebral malaria and African trypanosomiasis. His main research areas include:  Pathogen-induced brain encephalopathy and neuropathy associated with cerebral malaria and African trypanosomiasis.  He also develops interventions against Immunopathogenesis of CNS injury associated with sickle cell disease.  He utilizes bioinformatics, functional genomics, and proteomics in human, murine and in vitro models to study mechanisms mediating CNS pathology.
  • Neuregulin-1 Mitigates Kidney Injury in Humanized Sickle Cell Mice. Agbozo WK, Solomon W, Erskine IJ, Lekpor CE, Babayewa O, Bashi A, Harbuzariu A, Asberry A, Adel D, Adjei S, Paemka L, Ofori-Acquah SF, Stiles JK. FASEB J. 2026 May 31;40(10):e71910. doi: 10.1096/fj.202504449RR. PMID: 42160023.
  • Investigating SMR Peptide Interactions with Breast Cancer-Associated Proteins.

    Huang MB, Tiwari PB, Üren A, Shelton MN, Brena D, Wu JY, Khan MB, Powell MD, Stiles JK, Johnson EL, Yan F, Yang L, Bond VC. Int J Mol Sci. 2025 Sep 11;26(18):8848. doi: 10.3390/ijms26188848. PMID: 41009417.
  • Hydroxyurea Mitigates Heme-Induced Inflammation and Kidney Injury in Humanized Sickle Cell Mice. Agbozo WK, Solomon W, Lekpor CE, Erskine IJ, Oguljahan B, Bashi A, Harbuzariu A, Driss A, Adjei S, Paemka L, Ofori-Acquah SF, Stiles JK. Int J Mol Sci. 2025 Mar 30;26(7):3214. doi: 10.3390/ijms26073214. PMID: 40244015.
  • Circulating biomarkers associated with pediatric sickle cell disease. Lekpor CE, Botchway FA, Driss A, Bashi A, Abrahams AD, Kusi KA, Futagbi G, Alema-Mensah E, Agbozo W, Solomon W, Harbuzariu A, Adjei AA, Stiles JK. Front Mol Biosci. 2024 Dec 19;11:1481441. doi: 10.3389/fmolb.2024.1481441. eCollection 2024. PMID: 39749215.
  • Neuregulin-1/ErbB4 signaling modulates Plasmodium falciparum HRP2-induced damage to brain cortical organoids. Harbuzariu A, Nti A, Harp KO, Cespedes JC, Driss A, Stiles JK. iScience. 2022 May 14;25(6):104407. doi: 10.1016/j.isci.2022.104407. eCollection 2022 Jun 17. PMID: 35663028.
  • Thompson WE, Pattillo RA, Stiles JK, Schatten G. Biomedical research's unpaid debt: NIH's initiative to support and implement fairer competition for minority students is a welcome step to redress the exploitation of African Americans by science. EMBO Rep. 2014 Apr;15(4):333-7. doi: 10.1002/embr.201338274. Epub 2014 Mar 20. PMID: 24652854.
  • Solomon W, Wilson NO, Anderson L, Pitts S, Patrickson J, Liu M, Ford BD, Stiles JK. Neuregulin-1 attenuates mortality associated with experimental cerebral malaria. J Neuroinflammation. 2014 Jan 17;11:9. doi: 10.1186/1742-2094-11-9. PMID: 24433482.
  • Liu M, Wilson NO, Hibbert JM, Stiles JK. STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis. PLoS One. 2013 Aug 13;8(8):e71366. doi: 10.1371/journal.pone.0071366. eCollection 2013. PMID: 23967200.
  • Wilson NO, Solomon W, Anderson L, Patrickson J, Pitts S, Bond V, Liu M, Stiles JK. Pharmacologic inhibition of CXCL10 in combination with anti-malarial therapy eliminates mortality associated with murine model of cerebral malaria. PLoS One. 2013 Apr 5;8(4):e60898. doi: 10.1371/journal.pone.0060898. Print 2013. PMID: 23630573.
  • Liu M, Guo S, Stiles JK. The emerging role of CXCL10 in cancer (Review). Oncol Lett. 2011 Jul;2(4):583-589. Epub 2011 May 9. PMID: 22848232.
  • Hyacinth HI, Gee BE, Adamkiewicz TV, Adams RJ, Kutlar A,Stiles JK, Hibbert JM. Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia. Cytokine. 2012 Oct;60(1):302-8. doi: 10.1016/j.cyto.2012.05.017. Epub 2012 Jun 15. Erratum in: Cytokine. 2013 Apr;62(1):174. PMID: 22704695.



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