Long-term research interest of my laboratory includes developing comprehensive treatment/prevention
strategies for prostate, breast and ovarian cancer. These strategies are directed
to tumor cells and/or immune system using natural and synthetic products as a single
agent or in combination with conventional therapeutics.
Our research approach involves mechanistic studies to define the role of chemokines
in cancer metastasis (i.e. detachment, motility, adhesion, invasion, survival and
tumor growth at distant sites) as well as developing strategies to inhibit metastasis
and enhance chemotherapeutic efficacy. Additionally, we are developing methods to
overcome tumor induced immune suppression using natural products that treat/prevent
cancer as a single agent or in combination with traditional therapeutics.
Gupta P, Sharma PK, Mir H, Singh R, Singh N, Kloecker GH, Lillard JW Jr, Singh S. CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease
and mediates key steps of metastasis. Oncotarget. 2014 Sep 25. PMID: 25296976
Singh R, Gupta P, Kloecker GH, Singh S, Lillard JW Jr. Expression and clinical significance of CXCR5/CXCL13 in human non‑small
cell lung carcinoma. Int J Oncol. 2014 Dec;45(6):2232-40. doi: 10.3892/ijo.2014.2688. Epub 2014 Sep 30. PMID: 25271023
Rai D, Malhotra HS, Garg RK, Goel MM, Malhotra KP, Kumar V, Singh AK, Jain A, Kohli
N, Singh SK. Nerve abscess in primary neuritic leprosy. Lepr Rev. 2013 Jun;84(2):136-40. PMID: 24171239
Singh R, Gupta P, Sharma PK, Ades EW, Hollingshead SK, Singh S, Lillard JW. Prediction and characterization of helper T-cell epitopes from pneumococcal
surface adhesin A. Immunology. 2014 Apr;141(4):514-30. doi: 10.1111/imm.12194. PMID: 24138116
Kumar Goyal N, Goel A, Sankhwar SN, Mandal S, Singhai A, Singh S. Cheek metastasis from a bladder tumor: unusual presentation of an aggressive disease. Urologia. 2013 Sep-Dec;80(4):317-21. doi: 10.5301/urologia.5000022. Epub 2013 Jun 24. PMID: 23813285
El-Haibi CP, Sharma P, Singh R, Gupta P, Taub DD, Singh S, Lillard JW Jr. Differential G protein subunit expression by prostate cancer cells
and their interaction with CXCR5. Mol Cancer. 2013 Jun 18;12:64. doi: 10.1186/1476-4598-12-64. PMID: 23773523
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