Tx™: An Approach and Philosophy to
Advance Translation to Transformation
"T" represents the traditional and well- respected translational research continuum. Basic science discoveries, T0, may inform clinical research or trials among humans, or T1 translation. T2 translation is the study, facilitation, and application of research findings to patients with practice implications. T3 research involves clinical implementation, through research associated but not limited to adoption of interventions into routine patient care and may include health services or community-based participatory research. T4 is characterized by population-based studies that include life-style and behavioral modifications strategies, beyond the clinical setting that directly engage broader communities.
In the vast majority of instances, research findings take a very long time to impact clinical practice, patients, policy, and ultimately population health. Some discoveries never realize their potential in any large scale way. Moreover, even scientifically proven interventions that help one group are not nearly as effective in another group with the same problem. The translation of scientific discovery into meaningful gains in health therefore can be sluggish, often uncertain and/or uneven across the populations and not optimally facilitated by traditional siloed categories along the translational (T0-5) continuum.
We can do better. We will do better. There is a recognized need to improve the development and adoption of research discoveries that could have major impact at the scale of populations. It is also acknowledged that comprehensive solutions require a multiplicity of disciplines, perspectives, and interdisciplinary scientists (from biomedical, socio-cultural and behavioral) in collaboration—a collaboration characterized by consistent opportunities for focused communication and iterative interaction. This ideally would allow discovery, advance or insight gained in any phase of the "T" continuum to inform and enhance other phases of research or implementation.
What is Tx™?
Coined at Morehouse School of Medicine (MSM), Tx TM symbolizes an approach and scientific philosophy that intentionally promotes and supports convergence of interdisciplinary approaches and scientists to stimulate exponential advances for the health of diverse communities.
The "T" of the trademark acknowledges the importance of the phases of the translational continuum. However, the exponent "x" represents the goal to move research from the Translational to the Transformational.
How? By intentionally
- Engaging diverse disciplines and perspectives early in the process of identifying/framing the problem or opportunity and
- Bringing to bear different repositories of knowledge, skill and lived experience, Tx intends to gain richer, more effective solutions.
Therefore, MSM Tx is a comprehensive approach and philosophy, that advances the science, practice and evaluation of improving health outcomes. It addresses disparities by simultaneously engaging multiple disciplines as it recognizes the multiple layers and dimensions of complex health problems.
The aim of Tx is the advancement of health equity, which is the cornerstone of Morehouse School of Medicine's vision.
- Khoury MJ, et al. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genomic discoveries into health care and disease prevention? Genet Med 2007:9(10):665-674.
- National Center for Advancing Translational Sciences (2015, April) Translational Science Spectrum. Retrieved from https://ncats.nih.gov/translation/spectrum
- National Center for Advancing Translational Sciences (2015, April) Translational Science Fact Sheet. Retrieved from https://ncats.nih.gov/files/translation-factsheet.pdf
- Harvard Catalyst. (n.d), Pathfinder. Retrieved from http://catalyst.harvard.edu/pathfinder/
Research at MSM