Felix O. Aikhionbare, Ph.D. 

Associate Professor

Medicine

Phone: 404-752-1065
E-mail: faikhionbare@msm.edu

Education

GRADUATE:
The University of Nebraska
Degree: Doctor of Philosophy

Jackson State University
Degree: Master of Science


UNDERGRADUATE: 
Jackson State University
Degree: Bachelor of Science

Research Interests

My laboratory is dedicated to the molecular analysis of human ovarian and colorectal cancer. My overall goal is to identify differences between normal surrounding and cancerous ovarian and colorectal tissues, evaluate the consequences of these differences, and link this information to improve the clinical management of ovarian and colorectal cancer patients. Ongoing work is focused on the role of the mitochondrial genome alterations as modifier ‘genes’ in the progressive stages and dissecting the molecular basis of intra-tumor heterogeneity in ovarian and colorectal carcinoma. Other research project involved the evaluation of HLA-G gene mutations associated with prenatal transmission of HIV-1.

Clinical Interests

Cancer Biology

Host-HIV 1 pathogenesis

Specialties

Molecular Genetics

Publications

Lu H, Zhao Q, Jiang H, Zhu T, Xia P, Seffens W, Aikhionbare F, Wang D, Dou Z, Yao X. Characterization of ring-like f-actin structure as a mechanical partner for spindle positioning in mitosis. PLoS One. 2014 Oct 9;9(10):e102547. doi: 10.1371/journal.pone.0102547. eCollection 2014. PMID: 25299690

Liu X, Song Z, Huo Y, Zhang J, Zhu T, Wang J, Zhao X,Aikhionbare F, Zhang J, Duan H, Wu J, Dou Z, Shi Y, Yao X. Chromatin Protein HP1α Interacts with the Mitotic Regulator Borealin Protein and Specifies the Centromere Localization of the Chromosomal Passenger Complex. J Biol Chem. 2014 Jul 25;289(30):20638-20649. Epub 2014 Jun 10. PMID: 24917673

Zhu T, Dou Z, Qin B, Jin C, Wang X, Xu L, Wang Z, Zhu L, Liu F, Gao X, Ke Y, Wang Z, Aikhionbare F, Fu C, Ding X, Yao X. Phosphorylation of microtubule-binding protein Hec1 by mitotic kinase Aurora B specifies spindle checkpoint kinase Mps1 signaling at the kinetochore. J Biol Chem. 2013 Dec 13;288(50):36149-59. doi: 10.1074/jbc.M113.507970. Epub 2013 Nov 1. PMID: 24187132

Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X. ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin β1 recycling in cell migration. J Biol Chem. 2011 Dec 23;286(51):43735-47. doi: 10.1074/jbc.M111.278770. Epub 2011 Oct 25. PMID: 22027826

Chen Y, Wang D, Guo Z, Zhao J, Wu B, Deng H, Zhou T, Xiang H, Gao F, Yu X, Liao J, Ward T, Xia P, Emenari C, Ding X, Thompson W, Ma K, Zhu J, Aikhionbare F, Dou K, Cheng SY, Yao X. Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma. Cancer Res. 2011 Mar 1;71(5):1721-9. doi: 10.1158/0008-5472.CAN-09-4683. PMID: 21363921

Zhang L, Shao H, Huang Y, Yan F, Chu Y, Hou H, Zhu M, Fu C,Aikhionbare F, Fang G, Ding X, Yao X. PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity. J Biol Chem. 2011 Jan 28;286(4):3033-46. doi: 10.1074/jbc.M110.165340. Epub 2010 Nov 15. PMID: 21078677


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