Michael D. Powell, Ph.D. 

Associate Professor

Microbiology, Biochemistry & Immunology

Location: Research Wing
Phone: 404-752-1582
E-mail: mpowell@msm.edu

Education

GRADUATE:
The University of Texas at Dallas 
Degree: Doctor of Philosophy in Molecular and Cell Biology

The University of Texas at Dallas
Degree: Master of Science in Molecular and Cell Biology

The University of Texas at Arlington
Degree: Master of Science in Microbiology 


UNDERGRADUATE:
The University of Texas at Arlington
Degree: Bachelor of Science in Microbiology 

Research Interests

My research interests are in the role of extracellular vesicles (exosomes) in the pathogenesis of HIV/AIDS.  Our most recent project has focused on the role of Nef exosomes in the pathogenesis of HIV Associated Neurologic Disorders (HAND).  In the era of Anti-Retroviral Therapy (ART) the incidence of many complications of HIV/AIDS have been on the decrease.  HAND is one exception with certain varieties of this disorder are actually increasing.  An understanding of why this occurs will be important as HIV infected individuals live longer. 

I also run a Proteomics core lab.  We use nano-flow HPLC coupled to an ion trap mass spectrometer to do protein identification.  As a core lab we collaborate with many researchers at MSM doing a wide variety of different studies including Stroke, Cardiovascular diseases, Infectious diseases, Circadian rhythm disruption, and Reproduction.  

Publications

Shelton MN, Huang MB, Ali S, Johnson K, Roth W, Powell M, Bond V.Peptide-based Identification of Functional Motifs and their Binding Partners J Vis Exp. 2013 Jun 30;(76). doi: 10.3791/50362. PMID: 23852082

Campbell PE, Isayev O, Ali SA, Roth WW, Huang MB, Powell MD, Leszczynski J, Bond VC. Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling. J Mol Model. 2012 Oct;18(10):4603-13. doi: 10.1007/s00894-012-1452-x. Epub 2012 May PMID: 2264397

Omole FS, Lin JS, Chu T, Sow CM, Flood A, Powell MD. Raynaud's phenomenon, cytokines and acupuncture: a case report. Acupunct Med. 2012 Jun;30(2):139-41. PMID: 22516031

Shelton MN, Huang MB, Ali SA, Powell MD, Bond VC. Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release. J Virol. 2012 Jan;86(1):406-19. PMID: 22013042

Campbell PE, Isayev O, Ali SA, Roth WW, Huang MB, Powell MD, Leszczynski J, Bond VC. Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling. J Mol Model. 2012 May 30. PMID: 22643973

Medina GN, Ehrlich LS, Chen MH, Khan MB, Powell MD, Carter CA. Sprouty 2 Binds ESCRT-II Factor Eap20 and Facilitates HIV-1 Gag Release. J Virol. 2011 Jul;85(14):7353-62. Epub 2011 May 4. PMCID: PMC3126580


Click here to view additional publications.

Honors and Awards

2013: Outstanding Teaching Award (MSM 2nd year Medical Students) 

2012: Outstanding Teaching Award (MSM 2nd year Medical Students) 

2011: Outstanding Teaching Award (MSM 2nd year Medical Students) 

2009: Outstanding Teaching Award (MSM 2nd year Medical Students)