Pennsylvania State University
Pennsylvania State University College of Medicine
Degree: Doctor of Philosophy in Pharmacology
Hippocampal Structure, Function, and Malfunction in Temporal Lobe Epilepsy
The mammalian hippocampal formation subserves normal learning and memory, but when an injury to the temporal lobe occurs, the hippocampus can become a source of devastating epileptic seizures that often cannot currently be controlled. Our lab is interested in understanding how and why an injured hippocampus becomes spontaneously and abnormally hyperactive, and we develop animal models that replicate the human neurological disorder and can be used to develop new therapies.
Currently, we use chronically implanted electrodes and continuous recording methods that enable us to produce a controlled injury and then assess hippocampal hyperexcitability and epilepsy onset. In addition to in vivo electrophysiology, we use anatomical and immunocytochemical methods to characterize the pathology and determine how it is related to the epileptic state. Our most recent efforts focus on developing a treatment to stop seizures without producing significant side effects.
Sloviter RS. Progress on the issue of excitotoxic injury modification vs. real neuroprotection:
implications for post-traumatic epilepsy. Neuropharmacology 2011; 61:1048-1050.
Sloviter RS, Lømo T. Updating the lamellar hypothesis of hippocampal organization. Front Neural Circuits. 2012 Dec 10;6:102. doi: 10.3389/fncir.2012.00102.
Sloviter, R.S., Bumanglag, A.V., Defining “epileptogenesis” and identifying “antiepileptogenic targets” in animal models of acquired temporal lobe epilepsy is not as simple as it might seem, Neuropharmacology 69:3-15, 2013, doi: 10.1016/j.neuropharm.2012.01.022
Honors and Awards
Javits Neuroscience Investigator Award; awarded by NINDS
American Epilepsy Society Research Recognition Award
Decade of the Brain Lecturer, American Academy of Neurology
Fellow, American Association for the Advancement of Science
International Epilepsy Research Award, Amer. Soc. Pharm. and Experimental Therapeutics
First Swebelius Lecturer, Yale University, Department of Neurosurgery