Tiandong Leng, M.D., Ph.D.

Tiandong Leng, M.D., Ph.D. 

Assistant Professor

Neurobiology

Location: Multidisciplinary Research Center 218
Phone: (404) 756-6698
E-mail: tleng@msm.edu

Education

MEDICAL SCHOOL:
Weifang Medical University
Degree: Doctor of Medicine

GRADUATE:
Sun Yat-Sen University
Degree: Doctor of Philosophy in Pharmacology

Research Interests

Stroke

Ion channel

Neuroprotection

Neurosteroid

Publications

Zhou RP*, Leng TD*, Yang T, Chen FH, Wei H, Xiong ZG. β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation. Stroke. 2019 Aug 15. (*equal contribution)

 

Huang Y, Leng TD#, Inoue K, Yang T, Liu M, Horgen FD, Fleig A, Li J, Xiong ZG#. TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis. J Biol Chem. 2018 Sep 14;293(37):14393-14406. (#corresponding author)

 

Wu JJ*, Jiang N*, Leng TD*, Yang T, Jiang YQ, Zhou YF, Jiang Q, Wang B, Hu YJ, Ji YH, Simon RP, Chu XP, Xiong ZG, Zha XM. Region Specific Contribution of ASIC2 to Acidosis- and Ischemia-induced Neuronal Injury. J Cereb Blood Flow Metab. 2017 Feb;37(2):528-540. (*equal contribution)

 

Li MH*, Leng TD*, Feng XC, Yang T, Simon RP, and Xiong ZG. Modulation of ASIC1a by intracellular pH and its role in ischemic. J Biol Chem. 2016 Aug 26;291(35):18370-83. (*equal contribution)

 

Yan M, Liu AL, Zhou SJ, Tang LP, Ou YQ, Yin W, Chen XY, Su XW, Qiu PX, Huang YJ, Zhang JX, Yan GM, Leng TD#. Characterization of a synthetic 24-keto-cholest-5-en-3β, 19-Diol as a neuroprotectant. CNS Neuroscience&Therapeutics. 2015 Jun;21(6):486-95 (#corresponding author)

 

Hu HY*, Zhou YH*, Leng TD*, Liu AL, Wang YQ, Yin W, Huang YJ, Zhang JX, Qiu PX, Wang LW, Sang HF and Yan GM. The major cholesterol metabolite cholestane-3β, 5α, 6β-triol functions as an endogenous neuroprotectant. J Neurosci. 2014 Aug 20;34(34):11426-38 (*equal contribution)

 

Leng TD, Shi YJ, Xiong ZG, and Sun DD. Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke? Progress in Neurobiology. 2014 Apr;115:189-209