Tiandong Leng, M.D., Ph.D. 

Education

Research Interests

• Stroke
• Ion channel
• CNS Drug Development

Publications

• Baoming Wu, Jaree Bargaineer, Ling Zhang, Tao Yang, Zhigang Xiong and Tiandong Leng#. Upregulation of acid sensing ion channel 1a (ASIC1a) by hydrogen peroxide through JNK pathway, Acta Pharmacol Sin. 2021 Aug;42(8):1248-1255. (#corresponding author)
  
  
• Zhou RP*, Leng TD*, Yang T, Chen FH, Wei H, Xiong ZG. β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation. Stroke. 2019 Aug 15. (*equal contribution)
  
  
• Huang Y, Leng TD#, Inoue K, Yang T, Liu M, Horgen FD, Fleig A, Li J, Xiong ZG. TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis. J Biol Chem. 2018 Sep 14;293(37):14393-14406. (#corresponding author)
  
  
• Yan M, Liu AL, Zhou SJ, Tang LP, Ou YQ, Yin W, Chen XY, Su XW, Qiu PX, Huang YJ, Zhang JX, Yan GM, Leng TD#. Characterization of a synthetic 24-keto-cholest-5-en-3β, 19-Diol as a neuroprotectant. CNS Neuroscience&Therapeutics. 2015 Jun;21(6):486-95 (#corresponding author)
  
  
• Hu HY*, Zhou YH*, Leng TD*, Liu AL, Wang YQ, Yin W, Huang YJ, Zhang JX, Qiu PX, Wang LW, Sang HF and Yan GM. The major cholesterol metabolite cholestane-3β, 5α, 6β-triol functions as an endogenous neuroprotectant. J Neurosci. 2014 Aug 20;34(34):11426-38 (*equal contribution) 

Click to view additional publications: https://pubmed.ncbi.nlm.nih.gov/?term=tiandong+leng