University of Massachusetts Medical School
University of Pennsylvania School of Medicine
Senior Research Investigator: Pharmacology
University of Houston
Degree: Doctor of Philosophy in Cellular and Molecular Biology
Truman State University
Degree: Bachelor of Science in Biology
Life on our planet evolved in an ever-changing environment. One of the most extreme changes that affect most organisms is the same one that defines our ‘day’… the regular daily cycle between light and dark. This extreme, yet daily, environmental change presents a variety of challenges to nearly all organisms. In order to cope, nearly all organisms have evolved an inherent timing system – a ‘circadian’ clock – that helps organize their daily activity pattern, and many other rhythms, throughout the day. For example, it is easier to get a good night’s sleep if appetite, and urge to use the restroom, are suppressed at night.
Like all mammals, humans have circadian clocks almost every cell. These clocks, via driving daily rhythms in gene expression, ultimately drive daily rhythms in nearly all aspects of our physiology. These clocks are tightly synchronized to the environment directly by this light-dark cycle. However, changing the relationship between circadian clocks and the light-dark cycle, the result of shift-work and cause of jet-lag, can cause a wide-range of short-term and long-term problems. For example, people who regularly work on a rotation have an increased risk to develop some cancers, heart disease and obesity.
My lab is focused on identifying the genetic, molecular and biochemical mechanisms underlying circadian rhythms in mammals, including humans. In this pursuit, we develop and apply cutting edge genetic and genomic approaches to identify novel clockwork and sleep-regulatory mechanisms. Our ultimate goal is to discover new therapeutic targets and approaches to manipulate the both sleep and the circadian clock and lessen circadian clock-related disease risk.
DeBruyne JP, Weaver DR, Dallmann R. The hepatic circadian clock modulates xenobiotic metabolism
in mice. J Biol Rhythms. 2014 Aug;29(4):277-87. doi: 10.1177/0748730414544740. PMID: 25238856
Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. The transcription factor encyclopedia. Genome Biol. 2012;13(3):R24. doi: 10.1186/gb-2012-13-3-r24. PMID: 22458515
Dallmann R, DeBruyne JP, Weaver DR. Photic resetting and entrainment in CLOCK-deficient mice. J Biol Rhythms. 2011 Oct;26(5):390-401. doi: 10.1177/0748730411414345. PMID: 21921293
DeBruyne JP, Hogenesch JB. A CRY in the Night. Dev Cell. 2011 Feb 15;20(2):144-5. doi: 10.1016/j.devcel.2011.01.014. PMID: 21316582
Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul;29(14):3853-66. doi: 10.1128/MCB.00338-09. Epub 2009 May 4. PMID: 19414593
Debruyne JP. Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system. J Genet. 2008 Dec;87(5):437-46. Review. PMID: 19147932
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