Omar K. Danner, M.D., FACS

Binu Tharakan, Ph.D. 

Associate Professor

Surgery

Director of Research

Research Wing
Phone: (404) 752-1169
E-mail: btharakan@msm.edu

Education

Postdoctoral:
Texas A&M University College of Medicine & Baylor Scott and White, Temple, Texas, USA
National Institutes of Health, Bethesda, MD, USA
National Center for Biological Sciences, Bangalore, India

Graduate:
Banaras Hindu University, Varanasi, India
Degree: Doctor of Philosophy
Agra University, Agra, India
Degree: Master of Science

Undergraduate:
Mahatma Gandhi University, Kottayam, India
Degree: Bachelor of Science

Research Interests

Mechanisms of blood-brain barrier Dysfunction and brain edema following traumatic brain injury.
Neuroinflammatory pathways in microvascular hyperpermeability following traumatic injuries
New therapeutic strategies for brain edema following traumatic brain injury
Microvascular abnormalities following exposure to microgravity

 

Publications

Anasooya Shaji C, Robinson BD, Yeager A, Beeram MR, Davis ML, Isbell CL, Huang JH, Tharakan B. A tri-phasic role for hydrogen peroxide in blood-brain barrier endothelial cells. Scientific Reports. 9:133, 2019.
Robinson BD, Isbell CL, Shaji CA, Kurek S Jr, Regner JL, Tharakan B. Quetiapine protects the blood-brain barrier in traumatic brain injury. J Trauma. 85:968-976, 2018.
Alluri H, Grimsley M, Anasooya Shaji C, Varghese KP, Zhang SL, Peddaboina C, Robinson B, Beeram MR, Huang JH, Tharakan B. Attenuation of blood-brain barrier breakdown and hyperpermeability by calpain inhibition. J Biol Chem. 291:26958-26969, 2016.
Alluri H, Wilson RL, Anasooya Shaji C, Wiggins-Dohlvik K, Savan Patel, Yang Liu, Xu Peng, Beeram MR, Davis ML, Huang JH, Tharakan B. Melatonin preserves blood-brain barrier integrity and permeability by matrix metalloproteinase-9 inhibition. PLoS One, 11:e0154427, 2016
Wiggins-Dohlvik K, Oakley RP, Han MS, Stagg HW, Alluri H, Anasooya Shaji C, Davis ML, Tharakan B. Tissue inhibitor of metalloproteinases-2 inhibits burn induced derangements and hyperpermeability in microvascular endothelial cells. Am J Surg. 211:197-205, 2016.
Alluri H, Wiggins-Dohlvik K, Davis ML, Huang JH, Tharakan B. Blood-brain barrier dysfunction following traumatic brain injury. Metab Brain Dis. 30:1093-1104, 2015
Wiggins-Dohlvik K, Merriman M, Anasooya Shaji A, Grimsley M, Alluri H, Davis ML, Tharakan B. TNF-α disruption of brain endothelial cell barrier is mediated through matrix metalloproteinase-9 Am J Surg. 208:954-60, 2014.
Alluri H, Stagg HW, Wilson RL, Clayton RP, Sawant D, Koneru M, Beeram MR, Davis ML, Tharakan B. Reactive Oxygen Species-Caspase-3 Relationship in Mediating Blood-Brain Barrier Endothelial Cell Hyperpermeability Following Oxygen-Glucose Deprivation and Reoxygenation. Microcirculation. 21: 181-195, 2014.