Binu Tharakan, Ph.D.

Binu Tharakan, Ph.D. 

Associate Professor

Surgery

Location: Research MBU # 010
Phone: (404) 752-1169
E-mail: btharakan@msm.edu

Education

Postdoctoral:
Texas A&M University College of Medicine & Baylor Scott and White, Temple, Texas, USA
National Institutes of Health, Bethesda, MD, USA
National Center for Biological Sciences, Bangalore, India
 
Graduate:
Banaras Hindu University, Varanasi, India
Degree: Doctor of Philosophy
 
Agra University, Agra, India
Degree: Master of Science
 
Undergraduate:
Mahatma Gandhi University, Kottayam, India
Degree: Bachelor of Science

Research Interests

  • Traumatic Brain Injury: Mechanisms of Blood-Brain Barrier/Neurovascular Dysfunction and Cerebral Edema Formation Following Traumatic Brain injury.

  • Identification of Novel Therapeutic Targets for Cerebral Edema Formation Following Traumatic Brain Injury.

  • Mechanisms of Neurovascular Changes Associated with Exposure to Microgravity/Space Travel.

Publications

  • Maldonado J, Huang JH, Childs EW, Tharakan B (2023). Racial/Ethnic Differences in Traumatic Brain Injury: Pathophysiology, Outcomes, and Future Directions. J Neurotrauma. 40:502-513. PMID: 36029219.
  • Robinson BD, Isbell CL, Melge AR, Lomas AM, Shaji CA, Mohan CG, Huang JH, Tharakan B (2022). Sci Rep. Doxycycline prevents blood-brain barrier dysfunction and microvascular hyperpermeability after traumatic brain injury. Sci Reports. 2022,12:5415. PMID: 35354869 
  • Tharakan B, Hunter FA, Muthusamy S, Randolph S, Byrd C, Rao VN, Reddy ESP, Childs EW (2022). ETS-Related Gene Activation Preserves Adherens Junctions and Permeability in Microvascular Endothelial Cells. Shock, 2022, 57:309-315. 
  • Anasooya Shaji C, Robinson BD, Yeager A, Beeram MR, Davis ML, Isbell CL, Huang JH, Tharakan B (2019). The Tri-phasic Role of Hydrogen Peroxide in Blood-Brain Barrier Endothelial cells. Sci Rep. 9:133. PMID: 30644421 
  • Robinson BD, Isbell CL, Anasooya Shaji C, Kurek S Jr, Regner JL, Tharakan B (2018). Quetiapine protects the blood-brain barrier in traumatic brain injury. J Trauma Acute Care Surg. 85:968-976. PMID: 29985239
  • Alluri H, Grimsley M, Anasooya Shaji C, Varghese KP, Zhang SL, Peddaboina C, Robinson B, Beeram MR, Huang JH, Tharakan B (2016). Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition. J Biol Chem. 291:26958-26969. PMID: 27875293 
  • Alluri H, Wilson RL, Anasooya Shaji C, Wiggins-Dohlvik K, Patel S, Liu Y, Peng X, Beeram MR, Davis ML, Huang JH, Tharakan B (2016).  Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition. PLoS One. 11:e0154427. PMID: 27152411
  • Alluri H, Wiggins-Dohlvik K, Davis ML, Huang JH, Tharakan B (2015). Blood-brain barrier dysfunction following traumatic brain injury. Metab Brain Dis. 30:1093-104. PMID: 25624154