
Ed W. Childs, M.D.
Chair & Professor for Trauma and Critical Care
Surgery
Phone: (404) 616-1415
E-mail: echilds@msm.edu
Education
POSTGRADUATE:
University of California, Davis
Fellowship: Trauma/Critical Care
University of Kansas Medical Center in Kansas City
Residency: General Surgery
MEDICAL SCHOOL:
Texas A&M College of Medicine
Degree: Doctor of Medicine
UNDERGRADUATE:
University of Texas at Dallas
Degree: Bachelor of Arts in Molecular and Cellular Biology
Research Interests
Microvascular Injury Following Hemorrhagic Shock
Apoptotic Signaling Following Hemorrhagic Shock
Apoptotic Signaling Following Burn
Vascular Hyperpermeability
Tonsillar Abscess
Takayasu’s Arteritis
Gallbladder Carcinoma
Alpha Lipoic Acid Attenuates HS-induced Leukocyte Adherence
Challenging Trauma Cases
Contemporary Management of ARDS
Blunt Chest Trauma
Pelvic Fractures
Trauma and Pregnancy
Troponin I in the Evaluation of Blunt Myocardial Injury
Compartment Syndrome
SHOCK
Effect of Monoclonal Antibody LFA-1 on Leukocyte Adherence
Following Hemorrhagic Shock in Rats
WEB 2086 on Leukocyte Adherence Effects Following Hemorrhagic
Shock in Rat
Hemicorporectomy and Associated Complications
Leukocyte Dynamics
LA, Role of ROS Generation Following
Hemorrhagic Shock
Hypothermia Attenuates
Microvascular Permeability Following Hemorrhagic Shock
Evidence of Transcellular Permeability Following Hemorrhagic Shock
Fluid Management and Resuscitation of the Trauma Patient
Management and Resuscitation of the Trauma Patient
SHOCK, Halifax, Nova Scotia, Canada, Morphine’s effect on Venular Permeability and
Leukocyte Adherence
Experimental Biology 2005, San Diego, CA, Angiopoietin-1 Inhibits BAK (BH3)-Induced
Endothelial Cell Hyperpermeability
Cyclosporin A inhibits HS-induced Hyperpermeability
Inhibits Smac Release and Mitochondrial Transition Pores
Curcumin Attenuates Endothelial Cell Hyperpermeability by Inhibiting ROS Generation
Cyclosporin-A Attenuates Vascular Permeability in Hemorrhagic Shock through Anti-apoptotic
Mechanisms
Angiopoietin-1 Attenuates Microvascular Permeability and Decreases Cytoplasmic Smac
Levels Following Hemorrhagic Shock
Attenuates Hemorrhagic Shock-Induced Vascular Permeability and Caspase-3 Activity
Curcumin Attenuates Endothelial Cell Hyperpermeability by Inhibiting ROS Generation
Caspase-3 key Mediator of Vascular Hyperpermeability Following Hemorrhagic Shock
Alpha Lipoic Acid Inhibits Mitochondrial ROS Formation and Vascular Hyperpermability
Following Hemorrhagic Shock
17B-Estradiol Inhibits Apoptotic Signaling and Microvascular Endothelial Cell Hyperpermeability,
Sex and Gender in Cardiovascular Renal Physiology and Pathophysiology
Pathophysiology of Shock & Trauma
Mitochondrial Respiratory Chain Complex-III is Involved in BAK (BH3) Mediated ROS
Generation and Microvascular Endothelial Cell Hyperpermeability
Curcumin Prevents Vascular Hyperpermeability Following Hemorrhagic Shock
Alpha Lipoic Acid Prevents Microvascular Hyperpermeability By Acting Upstream of Caspase-3
Activation
(-) Deprenyl Attenuates Microvascular Endothelial Cell Hyperpermeability by Inhibiting
Intrinsic Apoptotic Signaling
17B-Estradiol Iinhibits Apoptotic Signaling and Microvascular Endothelial Cell Hyperpermeability
Alpha Lipoic Acid Inhibits Mitochondrial ROS Formation and Vascular Hyperpermeability Following
Hemorrhagic Shock
Caspase-3 is A Key Mediator of Vascular Hyperpermeability Following Hemorrhagic Shock
17B-Estradiol Inhibits Apoptotic Signaling and Microvascular Endothelial Cell Hyperpermeability
(-) Deprenyl Attenuates Vascular Hyperpermeability Following Hemorrhagic Shock
(-) Deprenyl attenuates Burn Induced-Hyperpermeability and Intrinsic Apoptotic Signaling in
Microvascular Endothelial Cells
Estradiol Inhibits Vascular Hyperpermeability Following Hemorrhagic Shock
Estrogen Receptors are involved in the 17-beta Estradiol Mediated Protection Against Microvascular
Endothelial Cell Hyperpermeability
Evidence for Endothelial Cell Adherens Junction Damage in Hemorrhagic Shock Induced
Hyperpermeability
Burn Injury Activates Intrinsic Apoptotic Signaling and Induces Vascular Hyperpermeability
17B-Estradiol Mediated Protection Against Vascular Hyperpermeability Following Hemorrhagic
Shock: Regulation of Estrogen Receptors
VE Cadherin Dynamics During Microvascular Endothelial Cell Hyperpermeability
Cyclosporin Inhibits Microvascular Endothelial Cell Hyperpermeability Iindependent
of Calcineurin Iinhibition
Apoptotic Signaling Regulates Vascular Hyperpermeability Following Hemorrhagic Shock
Hemorrhagic Shock Serum Induces ROS Formation, Activation of Apoptotic Signaling and
Endothelial Cell Monolayer Hyperpermeability
Vascular Hyperpermeability, Matrix Metalloproteinase 9 Induces Hyperpermeability Following Traumatic
Burn Injury
Regulation of Hemorrhagic Shock-Induced Vascular Hyperpermeability by 17β-Estradiol
Hemorrhagic Shock and Hyperpermeability
Hemorrhagic Shock-Induced Hyperpermeability
β-Catenin Cytoplasmic Stabilization Attenuates Microvascular Endothelial Cell Hyperpermeability.
Component Therapy in Trauma Resuscitation
Activation of a β-catenin Mediated Wnt Signaling Pathway in Microvascular Endothelial
Cells
(-) Deprenyl inhibits Microvascular Endothelial cell Hyperpermeabilty Independent
of MAO Inhibition
GSK-3β Inhibition attenuates vascular hyperpermeabiltiy following hemorrhagic shock Matrix
metalloproteinase-9 induces vascular hyperpermeability following traumatic burn
Role of Beta Catenin in Regulating Microvasclar Endothelial Cell Permeability
β-Catenin Cleavage and Microvascular Endothelial Cell Hyperpermeability Induced by
Staurosporine
Staurosporine induces brain microvascular endothelial cell hyperpermeability through
intrinsic apoptotic signaling pathway
TNF-α Induced Microvascular Endothelial Cell Hyperpermeability
Role of Mitochondrial Fission in Regulating Microvascular Endothelial Cell Hyperpermeability
Differential Involvement of IKKα and IKKβ in Regulating Microvascular Endothelial
Cell Barrier Integrity
MO, Role of B-Catenin in Regulating Microvascular Endothelial Cell Hyperpermeability
Board Certification
American Board of Surgery (General Surgery)
American Board of Surgery (Trauma and Critical Care)
Publications
Sawant DA, Tharakan B, Hunter FA, Childs EW. The Role of Intrinsic Apoptotic Signaling in Hemorrhagic Shock-Induced Microvascular
Endothelial Cell Barrier Dysfunction. J Cardiovasc Transl Res. 2014 Oct 3. PMID: 25277298
Stagg HW, Whaley JG, Tharakan B, Hunter FA, Jupiter D, Little DC, Davis ML, Smythe
WR, Childs EW. Doxycycline attenuates burn-induced microvascular hyperpermeability. J Trauma Acute Care Surg. 2013 Dec;75(6):1040-6; discussion 1046. doi: 10.1097/TA.0b013e3182aa9c79. PMID:
24256679
Cromer WE, Zawieja SD, Tharakan B, Childs EW, Newell MK, Zawieja DC. The effects of inflammatory cytokines on lymphatic endothelial
barrier function. Angiogenesis. 2014 Apr;17(2):395-406. doi: 10.1007/s10456-013-9393-2. Epub 2013 Oct 20. PMID:
24141404
Sawant DA, Tharakan B, Wilson RL, Stagg HW, Hunter FA, Childs EW. Regulation of tumor necrosis factor-α-induced microvascular endothelial cell hyperpermeability
by recombinant B-cell lymphoma-extra large. J Surg Res. 2013 Sep;184(1):628-37. doi: 10.1016/j.jss.2013.04.079. Epub 2013 May 23. PMID:
23731686
Stagg HW, Bowen KA, Sawant DA, Rodriguez M, Tharakan B, Childs EW. Tumor necrosis factor-related apoptosis-inducing ligand promotes microvascular endothelial
cell hyperpermeability through phosphatidylinositol 3-kinase pathway. Am J Surg. 2013 Apr;205(4):419-25. doi: 10.1016/j.amjsurg.2012.10.027. Epub 2013 Jan 31. PMID:
23375756
Sawant DA, Tharakan B, Tobin RP, Reilly J, Hunter FA, Newell MK, Smythe WR, Childs EW. Microvascular endothelial cell hyperpermeability induced by endogenous caspase 3 activator
staurosporine. J Trauma Acute Care Surg. 2013 Feb;74(2):516-23. doi: 10.1097/TA.0b013e31827a0620. PMID: 23354245
Click here to view additional publications.
Honors and Awards
Craig Charleston- 13th Annual Anesthesiology Resident Research
Rudy Puana- 14th Annual Anesthesiology Resident Research
Forum- Best Research and Presentation
Rudy Puana- 15th Annual Anesthesiology Resident Research
Forum- Best Research and Presentation
Georgia Holder-Haynes 16th Annual Society of Black Academic
Surgeons- Best Presentation
Georgia Holder-Haynes 1st Annual General Surgery Research Forum
Best Research
John Ingraham Texas Society of Plastic Surgeon 2nd place, Basic Science