Ed W. Childs, M.D.

Ed W. Childs, M.D. 

Chair & Professor for Trauma and Critical Care


Phone: (404) 616-1415
E-mail: echilds@msm.edu


University of California, Davis
Trauma/Critical Care

University of Kansas Medical Center in Kansas City
General Surgery


Texas A&M College of Medicine
Degree: Doctor of Medicine

University of Texas at Dallas
Degree: Bachelor of Arts in Molecular and Cellular Biology

Research Interests

Microvascular Injury Following Hemorrhagic Shock
Apoptotic Signaling Following Hemorrhagic Shock
Apoptotic Signaling Following Burn
Vascular Hyperpermeability
Tonsillar Abscess   
Takayasu’s Arteritis  
Gallbladder Carcinoma
Alpha Lipoic Acid Attenuates HS-induced Leukocyte Adherence
Challenging Trauma Cases
Contemporary Management of ARDS 
Blunt Chest Trauma
Pelvic Fractures
Trauma and Pregnancy
Troponin I in the Evaluation of Blunt Myocardial Injury
Compartment Syndrome

Effect of Monoclonal Antibody LFA-1 on Leukocyte Adherence
Following Hemorrhagic Shock in Rats
WEB 2086 on Leukocyte Adherence Effects Following Hemorrhagic

Shock in Rat
Hemicorporectomy and Associated Complications
Leukocyte Dynamics     
LA, Role of ROS Generation Following
Hemorrhagic Shock    
Hypothermia Attenuates
Microvascular Permeability Following Hemorrhagic Shock
Evidence of Transcellular Permeability Following Hemorrhagic Shock
Fluid Management and Resuscitation of the Trauma Patient  
Management and Resuscitation of the Trauma Patient   
SHOCK, Halifax, Nova Scotia, Canada, Morphine’s effect on Venular Permeability and Leukocyte Adherence    
Experimental Biology 2005, San Diego, CA, Angiopoietin-1 Inhibits BAK (BH3)-Induced Endothelial Cell Hyperpermeability
Cyclosporin A inhibits HS-induced Hyperpermeability
Inhibits Smac Release and Mitochondrial Transition Pores 
Curcumin Attenuates Endothelial Cell Hyperpermeability by Inhibiting ROS Generation 
Cyclosporin-A Attenuates Vascular Permeability in Hemorrhagic Shock through Anti-apoptotic Mechanisms
Angiopoietin-1 Attenuates Microvascular Permeability and Decreases Cytoplasmic Smac Levels Following Hemorrhagic Shock
Attenuates Hemorrhagic Shock-Induced Vascular Permeability and Caspase-3 Activity
Curcumin Attenuates Endothelial Cell Hyperpermeability by Inhibiting ROS Generation     Caspase-3 key Mediator of Vascular Hyperpermeability Following Hemorrhagic Shock
Alpha Lipoic Acid Inhibits Mitochondrial ROS Formation and Vascular Hyperpermability Following Hemorrhagic Shock
17B-Estradiol Inhibits Apoptotic Signaling and Microvascular Endothelial Cell Hyperpermeability, Sex and Gender in Cardiovascular Renal Physiology and Pathophysiology
Pathophysiology of Shock & Trauma    
Mitochondrial Respiratory Chain Complex-III is Involved in BAK (BH3) Mediated ROS Generation and Microvascular Endothelial Cell Hyperpermeability  
Curcumin Prevents Vascular Hyperpermeability Following Hemorrhagic Shock
Alpha Lipoic Acid Prevents Microvascular Hyperpermeability By Acting Upstream of Caspase-3 Activation  
(-) Deprenyl Attenuates Microvascular Endothelial Cell Hyperpermeability by Inhibiting Intrinsic Apoptotic Signaling 
17B-Estradiol Iinhibits Apoptotic Signaling and Microvascular Endothelial Cell Hyperpermeability
Alpha Lipoic Acid Inhibits Mitochondrial ROS Formation and Vascular Hyperpermeability Following Hemorrhagic Shock 
Caspase-3 is A Key Mediator of Vascular Hyperpermeability Following Hemorrhagic Shock
17B-Estradiol Inhibits Apoptotic Signaling and Microvascular Endothelial Cell Hyperpermeability
(-) Deprenyl Attenuates Vascular Hyperpermeability Following Hemorrhagic Shock
(-) Deprenyl attenuates Burn Induced-Hyperpermeability and Intrinsic Apoptotic Signaling in Microvascular Endothelial Cells
Estradiol Inhibits Vascular Hyperpermeability Following Hemorrhagic Shock
Estrogen Receptors are involved in the 17-beta Estradiol Mediated Protection Against Microvascular Endothelial Cell Hyperpermeability
Evidence for Endothelial Cell Adherens Junction Damage in Hemorrhagic Shock Induced Hyperpermeability
Burn Injury Activates Intrinsic Apoptotic Signaling and Induces Vascular Hyperpermeability
17B-Estradiol Mediated Protection Against Vascular Hyperpermeability Following Hemorrhagic Shock: Regulation of Estrogen Receptors
VE Cadherin Dynamics During Microvascular Endothelial Cell Hyperpermeability
Cyclosporin Inhibits Microvascular Endothelial Cell Hyperpermeability Iindependent of Calcineurin Iinhibition
Apoptotic Signaling Regulates Vascular Hyperpermeability Following Hemorrhagic Shock 
Hemorrhagic Shock Serum Induces ROS Formation, Activation of Apoptotic Signaling and Endothelial Cell Monolayer Hyperpermeability 
Vascular Hyperpermeability, Matrix Metalloproteinase 9 Induces Hyperpermeability Following Traumatic Burn Injury
Regulation of Hemorrhagic Shock-Induced Vascular Hyperpermeability by 17β-Estradiol
Hemorrhagic Shock and Hyperpermeability
Hemorrhagic Shock-Induced Hyperpermeability  
β-Catenin Cytoplasmic Stabilization Attenuates Microvascular Endothelial Cell Hyperpermeability.
Component Therapy in Trauma Resuscitation
Activation of a β-catenin Mediated Wnt Signaling Pathway in Microvascular Endothelial Cells     
(-) Deprenyl inhibits Microvascular Endothelial cell Hyperpermeabilty Independent of MAO Inhibition
GSK-3β Inhibition attenuates vascular hyperpermeabiltiy following hemorrhagic shock Matrix metalloproteinase-9 induces vascular hyperpermeability following traumatic burn
Role of Beta Catenin in Regulating Microvasclar Endothelial Cell Permeability    
β-Catenin Cleavage and Microvascular Endothelial Cell Hyperpermeability Induced by Staurosporine 
Staurosporine induces brain microvascular endothelial cell hyperpermeability through intrinsic apoptotic signaling pathway 
TNF-α Induced Microvascular Endothelial Cell Hyperpermeability
Role of Mitochondrial Fission in Regulating Microvascular Endothelial Cell Hyperpermeability
Differential Involvement of IKKα and IKKβ in Regulating Microvascular Endothelial Cell Barrier Integrity
MO, Role of B-Catenin in Regulating Microvascular Endothelial Cell Hyperpermeability 

Board Certification

American Board of Surgery (General Surgery)

American Board of Surgery (Trauma and Critical Care)


Sawant DA, Tharakan B, Hunter FA, Childs EW.  The Role of Intrinsic Apoptotic Signaling in Hemorrhagic Shock-Induced Microvascular Endothelial Cell Barrier Dysfunction. J Cardiovasc Transl Res. 2014 Oct 3. PMID: 25277298

Stagg HW, Whaley JG, Tharakan B, Hunter FA, Jupiter D, Little DC, Davis ML, Smythe WR, Childs EW.  Doxycycline attenuates burn-induced microvascular hyperpermeability. J Trauma Acute Care Surg. 2013 Dec;75(6):1040-6; discussion 1046. doi: 10.1097/TA.0b013e3182aa9c79. PMID: 24256679

Cromer WE, Zawieja SD, Tharakan B, Childs EW, Newell MK, Zawieja DC. The effects of inflammatory cytokines on lymphatic endothelial barrier function. Angiogenesis. 2014 Apr;17(2):395-406. doi: 10.1007/s10456-013-9393-2. Epub 2013 Oct 20. PMID: 24141404

Sawant DA, Tharakan B, Wilson RL, Stagg HW, Hunter FA, Childs EW. Regulation of tumor necrosis factor-α-induced microvascular endothelial cell hyperpermeability by recombinant B-cell lymphoma-extra large. J Surg Res. 2013 Sep;184(1):628-37. doi: 10.1016/j.jss.2013.04.079. Epub 2013 May 23. PMID: 23731686

Stagg HW, Bowen KA, Sawant DA, Rodriguez M, Tharakan B, Childs EW. Tumor necrosis factor-related apoptosis-inducing ligand promotes microvascular endothelial cell hyperpermeability through phosphatidylinositol 3-kinase pathway. Am J Surg. 2013 Apr;205(4):419-25. doi: 10.1016/j.amjsurg.2012.10.027. Epub 2013 Jan 31. PMID: 23375756

Sawant DA, Tharakan B, Tobin RP, Reilly J, Hunter FA, Newell MK, Smythe WR, Childs EW.  Microvascular endothelial cell hyperpermeability induced by endogenous caspase 3 activator staurosporine. J Trauma Acute Care Surg. 2013 Feb;74(2):516-23. doi: 10.1097/TA.0b013e31827a0620. PMID: 23354245

Click here to view additional publications. 

Honors and Awards

Craig Charleston- 13th Annual Anesthesiology Resident Research                  

Rudy Puana- 14th Annual Anesthesiology Resident Research  
Forum- Best Research and Presentation

Rudy Puana- 15th Annual Anesthesiology Resident Research
Forum- Best Research and Presentation

Georgia Holder-Haynes 16th Annual Society of Black Academic   
Surgeons- Best Presentation

Georgia Holder-Haynes 1st Annual General Surgery Research Forum  
Best Research     

John Ingraham Texas Society of Plastic Surgeon 2nd place, Basic Science